2. Gene
  3. CARF - calcium responsive transcription factor Gene

CARF - calcium responsive transcription factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙反应转录因子

种属: Homo sapiens

同用名: ALS2CR8; NYD-SP24

基因 ID: 79800 | 基因类型: protein coding

关于 CARF

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:202,912,275-202,988,263 (from NCBI)

This gene has 20 transcripts (splice variants) and 172 orthologues. Broad expression in testis (RPKM 5.9), thyroid (RPKM 3.4) and 24 other tissues.

功能概要

启用 DNA 结合活性和 DNA 结合转录因子活性。参与细胞对钾离子的反应和对钙离子反应的 RNA 聚合酶 II 启动子转录的正调控。预测位于颗粒状组件中。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in cellular response to potassium ion and positive regulation of transcription from RNA polymerase II promoter in response to calcium ion. Predicted to be located in granular component. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CARF 基因产物(12)

mRNA Protein Name
NM_001104586.4 NP_001098056.1 calcium-responsive transcription factor isoform 1
NM_001282910.3 NP_001269839.1 calcium-responsive transcription factor isoform 2
NM_001282911.3 NP_001269840.1 calcium-responsive transcription factor isoform 2
NM_001282912.3 NP_001269841.1 calcium-responsive transcription factor isoform 3
NM_001322427.3 NP_001309356.1 calcium-responsive transcription factor isoform 1
NM_001322428.3 NP_001309357.1 calcium-responsive transcription factor isoform 1
NM_001322429.3 NP_001309358.1 calcium-responsive transcription factor isoform 4
NM_001352676.2 NP_001339605.1 calcium-responsive transcription factor isoform 6
NM_001352677.2 NP_001339606.1 calcium-responsive transcription factor isoform 7
NM_001352678.2 NP_001339607.1 calcium-responsive transcription factor isoform 8
NM_001352679.2 NP_001339608.1 calcium-responsive transcription factor isoform 8
NM_024744.17 NP_079020.13 calcium-responsive transcription factor isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11832226 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11832226 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to calcium ion IDA
IDA: 通过直接分析推断
11832226 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CARF 蛋白结构

ALS2CR8

ALS2CR8: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 (251 - 483)

  • 0
  • 200
  • 400
  • 600
  • 725 a.a.
蛋白主名 其他名称

calcium-responsive transcription factor

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8

CARF 抗体

目录号 产品名 应用 反应物种
HY-P82330 ALS2CR8 Antibody (YA2075) WB Human

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis 2, Juvenile

ALS2

Als, Juvenile

Alsj

Amyotrophic Lateral Sclerosis Type 2

Amyotrophic Lateral Sclerosis 2

Amyotrophic Lateral Sclerosis Type 2, Juvenile

Amyotrophic Lateral Sclerosis Juvenile

Amyotrophic Lateral Sclerosis Juvenile 2

Sclerosis, Lateral, Amyotrophic, Type Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01924 CARF Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CARF VGNC VGNC:38719
Mus musculus CARF MGD MGI:2182269
Macaca mulatta CARF VGNC VGNC:70518
Felis catus CARF VGNC VGNC:107493
Rattus norvegicus CARF RGD RGD:1306822
Bos taurus CARF VGNC VGNC:26765
Others CARF NCBI
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