1. Gene
  2. CAMK2A - calcium/calmodulin dependent protein kinase II alpha Gene

CAMK2A - calcium/calmodulin dependent protein kinase II alpha Gene

中文名称:钙/钙调蛋白依赖性蛋白激酶 II α

种属: Homo sapiens

同用名: CAMKA; MRD53; MRT63; CaMKIIalpha; CaMKIINalpha

基因 ID: 815 | 基因类型: protein coding

关于 CAMK2A

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,219,491-150,290,130 (from NCBI)

This gene has 23 transcripts (splice variants), 167 orthologues, 22 paralogues and is associated with 4 phenotypes. Restricted expression toward brain (RPKM 112.2).

功能概要

该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族,以及 Ca (2+) /钙调蛋白依赖性蛋白激酶亚家族。钙信号对于谷氨酸能突触可塑性的几个方面至关重要。这种钙调蛋白依赖性蛋白激酶由四种不同的链组成:α、β、γ 和 δ。由该基因编码的 alpha 链是海马长时程增强 (LTP) 和空间学习所必需的。除了其钙钙调蛋白 (CaM) 依赖性活性外,该蛋白质还可以进行自身磷酸化,从而产生 CaM 非依赖性活性。已经为该基因鉴定了几种编码不同亚型的转录物变体。[RefSeq 提供,2018 年 6 月]

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]

CAMK2A 基因产物(5)

mRNA Protein Name
NM_015981.4 NP_057065.2 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1
NM_001369025.2 NP_001355954.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3
NM_171825.3 NP_741960.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001363990.1 NP_001350919.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001363989.1 NP_001350918.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

CAMK2A 蛋白结构

Pkinase

Pkinase: Protein kinase domain (13 - 271)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (346 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
蛋白主名 其他名称

calcium/calmodulin-dependent protein kinase type II subunit alpha

CaM kinase II alpha subunit

CaM-kinase II alpha chain

CaMK-II alpha subunit

caM kinase II subunit alpha

caMK-II subunit alpha

calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha

calcium/calmodulin-dependent protein kinase II alpha-B subunit

calcium/calmodulin-dependent protein kinase type II alpha chain

重组 CAMK2A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76761 CaMKII alpha/CAMK2A Protein, Human (sf9, GST) Q9UQM7-1 (M1-H478) ≥95%

关联疾病

疾病名称 别名
Rett Syndrome

Atypical Rett Syndrome

RTT

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Atypical

Rett Syndrome, Preserved Speech Variant

Rett'S Disorder

Rett Syndrome Variant

Rett Disorder

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Intellectual Developmental Disorder, Autosomal Recessive 63

MRT63

Mental Retardation, Autosomal Recessive 63

Intellectual Developmental Disorder, Autosomal Dominant 53

MRD53

Mental Retardation, Autosomal Dominant 53

Autosomal Dominant Intellectual Developmental Disorder 53

Autosomal Dominant Mental Retardation 53

Mental Retardation, Autosomal Dominant, Type 53

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Autosomal Dominant Non-Syndromic Intellectual Disability
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CAMK2A VGNC VGNC:38680
Macaca mulatta CAMK2A VGNC VGNC:70523
Bos taurus CAMK2A VGNC VGNC:26721
Rattus norvegicus CAMK2A RGD RGD:2261
Felis catus CAMK2A VGNC VGNC:60331
Mus musculus CAMK2A MGD MGI:88256
Others CAMK2A NCBI