2. Gene
  3. Smad7 - SMAD family member 7 Gene

Smad7 - SMAD family member 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Madh7

基因 ID: 81516 | 基因类型: protein coding

关于 Smad7

功能概要

Enables ubiquitin protein Ligase binding activity. Involved in intracellular signal transduction; negative regulation of transcription, DNA-templated; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including centrosome; cytosol; and nuclear lumen. Predicted to be part of heteromeric SMAD protein complex. Predicted to colocalize with adherens junction. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in colorectal Cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (Smad Family member 7). [provided by Alliance of Genome Resources, Apr 2022]

Smad7 基因产物(1)

mRNA Protein Name
NM_030858.2 NP_110485.1 mothers against decapentaplegic homolog 7
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18762808 RGD
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
17347560 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
11959632 RGD
involved in negative regulation of DNA-templated transcription IEP
IEP: 通过表达模式推断
11959632 RGD
involved in regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
11959632 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mothers against decapentaplegic homolog 7

MAD (mothers against decapentaplegic, Drosophila) homolog 7

MAD homolog 7

SMAD 7

mothers against DPP homolog 7

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0439 Asiaticoside 99.67% 否
HY-145721A Mongersen sodium 99.61% 否
HY-145721 Mongersen Inhibitor / 否
HY-170791 CIB-L43 99.71% 否
HY-120268A SLM6031434 hydrochloride Inhibitor 99.1% 否
HY-RS13398 SMAD7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-120268 SLM6031434 Inhibitor / 否
HY-175662 TGF-β/Smad-IN-2 Inhibitor / 否
HY-N13208 Stevia Powder / 否
HY-RS18408 Smad7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24889 Smad7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smad7 NCBI NCBI:4092
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