2. Gene
  3. Nedd4l - neural precursor cell expressed, developmentally down-regulated gene 4-like Gene

Nedd4l - neural precursor cell expressed, developmentally down-regulated gene 4-like Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nedd4b; NEDD4.2; Nedd4-2; 1300012C07Rik

基因 ID: 83814 | 基因类型: protein coding

关于 Nedd4l

功能概要

Enables Sodium Channel Inhibitor activity and ubiquitin protein Ligase activity. Acts upstream of or within several processes, including negative regulation of systemic arterial blood pressure; regulation of bicellular tight junction assembly; and regulation of ion transport. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and retina. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Nedd4l 基因产物(6)

mRNA Protein Name
NM_001114386.2 NP_001107858.1 E3 ubiquitin-protein ligase NEDD4-like isoform 1
NM_001404007.1 NP_001390936.1 E3 ubiquitin-protein ligase NEDD4-like isoform 3
NM_001404008.1 NP_001390937.1 E3 ubiquitin-protein ligase NEDD4-like isoform 4
NM_001404009.1 NP_001390938.1 E3 ubiquitin-protein ligase NEDD4-like isoform 4
NM_001404013.1 NP_001390942.1 E3 ubiquitin-protein ligase NEDD4-like isoform 5
NM_031881.3 NP_114087.2 E3 ubiquitin-protein ligase NEDD4-like isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17544362 MGI
enables sodium channel inhibitor activity IDA
IDA: 通过直接分析推断
11149908 MGI
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
20504882 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of establishment of localization in cell IMP
IMP: 通过突变表型推断
21300902 MGI
acts upstream of or within negative regulation of sodium ion transport IDA
IDA: 通过直接分析推断
11149908 MGI
acts upstream of or within negative regulation of sodium ion transport IMP
IMP: 通过突变表型推断
18524855 MGI
acts upstream of or within negative regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
18524855 MGI
acts upstream of or within positive regulation of cation channel activity IGI
IGI: 通过遗传相互作用推断
18981174 MGI
acts upstream of or within positive regulation of sodium ion transport IGI
IGI: 通过遗传相互作用推断
18981174 MGI
acts upstream of or within regulation of bicellular tight junction assembly IDA
IDA: 通过直接分析推断
20504882 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
28212375 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: 通过表达模式推断
28212375 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
28212375 MGI
acts upstream of or within regulation of sodium ion transport IDA
IDA: 通过直接分析推断
32175648 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
28212375 MGI
involved in regulation protein catabolic process at postsynapse IEP
IEP: 通过表达模式推断
28212375 MGI
involved in regulation protein catabolic process at postsynapse IMP
IMP: 通过突变表型推断
28212375 MGI
acts upstream of or within response to salt stress IMP
IMP: 通过突变表型推断
18524855 MGI
acts upstream of sodium ion transport IMP
IMP: 通过突变表型推断
18524855 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
32175648 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
28212375 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
28212375 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
28212375 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase NEDD4-like

HECT-type E3 ubiquitin transferase NED4L

neural precursor cell expressed, developmentally down-regulated gene 4b

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09180 NEDD4L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17116 Nedd4l Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23561 Nedd4l Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nedd4l NCBI NCBI:23327
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