IL17RC - interleukin 17 receptor C Gene

中文名称：白介素 17 受体 C

种属: Homo sapiens

同用名: CANDF9; IL17RL; IL17-RL

基因 ID: 84818 | 基因类型: protein coding

关于 IL17RC

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,917,098-9,933,621 (from NCBI)

This gene has 47 transcripts (splice variants), 127 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 15.4), skin (RPKM 9.6) and 25 other tissues.

功能概要

该基因编码单程 I 型膜蛋白，与白细胞介素 17 受体 (IL-17RA) 具有相似性。与主要在造血细胞中表达并仅与 IL-17A 以高亲和力结合的 IL-17RA 不同，该蛋白在非造血组织中表达，并以相似的亲和力结合 IL-17A 和 IL-17F。促炎细胞因子 IL-17A 和 IL-17F 与炎症和自身免疫性疾病的进展有关。已检测到该基因编码不同亚型的多个选择性剪接转录变体，并且有人提出，缺乏跨膜和细胞内结构域的可溶性分泌蛋白可能作为细胞因子信号转导的细胞外拮抗剂发挥作用。[RefSeq 提供，2011 年 2 月]

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

IL17RC 基因产物(10)

mRNA	Protein	Name
NM_001203263.2	NP_001190192.2	interleukin-17 receptor C isoform 4 precursor
NM_001203264.2	NP_001190193.2	interleukin-17 receptor C isoform 5 precursor
NM_001203265.2	NP_001190194.2	interleukin-17 receptor C isoform 6 precursor
NM_001367278.1	NP_001354207.1	interleukin-17 receptor C isoform 7 precursor
NM_001367279.1	NP_001354208.1	interleukin-17 receptor C isoform 8 precursor
NM_001367280.1	NP_001354209.1	interleukin-17 receptor C isoform 9 precursor
NM_001410711.1	NP_001397640.1	interleukin-17 receptor C isoform 10 precursor
NM_032732.6	NP_116121.3	interleukin-17 receptor C isoform 3 precursor
NM_153460.4	NP_703190.2	interleukin-17 receptor C isoform 1 precursor
NM_153461.4	NP_703191.2	interleukin-17 receptor C isoform 2 precursor

IL17RC 蛋白结构

IL17_R_N

SEFIR

0
200
400
600
791 a.a.

蛋白主名

其他名称

interleukin-17 receptor C

IL-17 receptor C

重组 IL17RC 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72580	IL-17RC Protein, Human (434a.a, HEK293, Fc)	Q8NAC3-3 (L21-A454)	≥95%
HY-P75837	IL-17RC Protein, Human (sf9, His)	Q8NAC3-3 (M1-A454)	≥95%
HY-P75838	IL-17RC Protein, Human (454a.a, HEK293, Fc)	Q8NAC3-3 (M1-A454)	≥95%

关联疾病

疾病名称

别名

Candidiasis, Familial, 9

CANDF9

Candidiasis, Familial, Type 9

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Immunodeficiency 29

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency	IMD29
Il12b Deficiency	Immunodeficiency 29, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency	Msmd Due To Complete Il12b Deficiency
Msmd Due To Complete Interleukin 12b Deficiency	Immunodeficiency, Type 29, Mycobacteriosis

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Cutaneous Candidiasis

Candidiasis, Cutaneous

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome	Hyper-Ige Recurrent Infection Syndrome 1
Hyperimmunoglobulin E Syndrome	Job'S Syndrome
Recurring Cold Staphylococcal Abscesses	Ige Syndromes
Buckley Syndrome	Hie - [Hyperimmunoglobulin E] Syndrome
Job-Buckley Syndrome	Quie-Hill Syndrome

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Candidal Paronychia

Candidiasis Of Skin	Candidiasis Of Skin And Nails
Candidal Perionyxis

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Oral Candidiasis

Thrush	Candidiasis Of Mouth
Oral Moniliasis	Thrush, Oral
Candidiasis, Oral	Oral Thrush
Candidiasis	Equine Thrush

Autoimmune Polyendocrine Syndrome Type 1

Whitaker Syndrome	Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
Autoimmune Polyglandular Syndrome I	Polyglandular Type I Autoimmune Syndrome

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Fungal Infectious Disease

Mycoses

Mycosis

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Scoliosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06704	IL17RC Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	IL17RC	VGNC	VGNC:30123
Macaca mulatta	IL17RC	VGNC	VGNC:84164
Rattus norvegicus	IL17RC	RGD	RGD:1306392
Mus musculus	IL17RC	MGD	MGI:2159336
Felis catus	IL17RC	VGNC	VGNC:62903
Canis familiaris	IL17RC	VGNC	VGNC:41948
Others	IL17RC	NCBI

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IL17RC - interleukin 17 receptor C Gene

关于 IL17RC

功能概要

IL17RC 基因产物(10)

IL17RC 蛋白结构

重组 IL17RC 蛋白

关联疾病

直系同源

热门区域

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IL17RC - interleukin 17 receptor C Gene

关于 IL17RC

功能概要

IL17RC 基因产物(10)

IL17RC 蛋白结构

重组 IL17RC 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z