TNFSF14 - TNF superfamily member 14 Gene

中文名称：TNF 超家族成员 14

种属: Homo sapiens

同用名: LTg; CD258; HVEML; LIGHT

关于 TNFSF14

功能概要

该基因编码的蛋白质是肿瘤坏死因子 (TNF) 配体家族的成员。该蛋白是 TNFRSF14 的配体，TNFRSF14 是肿瘤坏死因子受体超家族的成员，也称为疱疹病毒进入介质 (HVEM) 。这种蛋白质可能作为淋巴样细胞活化的共刺激因子发挥作用，并作为疱疹病毒感染的威慑剂。这种蛋白质已被证明可以刺激 T 细胞的增殖，并引发各种肿瘤细胞的凋亡。据报道，该蛋白质还可防止原发性肝细胞中肿瘤坏死因子 α 介导的细胞凋亡。已经报道了编码不同亚型的两种可变剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to Infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger Apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated Apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]