PROZ - protein Z, vitamin K dependent plasma glycoprotein Gene

中文名称：蛋白 Z，维生素 K 依赖性血浆糖蛋白

种属: Homo sapiens

同用名: PZ

关于 PROZ

功能概要

该基因编码一种在肝脏中合成并分泌到血浆中的肝脏维生素 K 依赖性糖蛋白。所编码的蛋白质通过与蛋白 Z 依赖性蛋白酶抑制剂复合，直接抑制磷脂表面的活化因子 X，从而发挥调节血液凝固的作用。这种蛋白质的缺乏与缺血性动脉疾病和胎儿丢失的风险增加有关。该基因的突变是蛋白质 Z 缺乏症的原因。交替剪接导致多个转录本变体。[RefSeq 提供，2012 年 1 月]

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]