NEMF - nuclear export mediator factor Gene

中文名称：核出口中介因子

种属: Homo sapiens

同用名: RQC2; IDDSAPN; NY-CO-1; SDCCAG1

基因 ID: 9147 | 基因类型: protein coding

关于 NEMF

Cytogenetic location: 14q21.3 Genomic coordinates (GRCh38): 14:49,782,083-49,852,788 (from NCBI)

This gene has 15 transcripts (splice variants), 203 orthologues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 12.2), thyroid (RPKM 10.8) and 25 other tissues.

功能概要

该基因编码核糖体质量控制复合物的一个组成部分。编码的蛋白质有助于泛素连接酶李斯特素对停滞的 60S 亚基的识别和泛素化。果蝇中的一种类似蛋白质起着肿瘤抑制因子的作用。[RefSeq 提供，2016 年 7 月]

This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin Ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]

NEMF 基因产物(2)

mRNA	Protein	Name
NM_001301732.3	NP_001288661.2	ribosome quality control complex subunit NEMF isoform 2
NM_004713.6	NP_004704.3	ribosome quality control complex subunit NEMF isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alpha-aminoacyl-tRNA binding	IDA IDA: 通过直接分析推断	33406423	GOA
enables ribosomal large subunit binding	IDA IDA: 通过直接分析推断	25578875	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in CAT tailing	IDA IDA: 通过直接分析推断	33406423	GOA
involved in nuclear export	IMP IMP: 通过突变表型推断	16103875	GOA
involved in protein-containing complex assembly	IMP IMP: 通过突变表型推断	25578875	GOA
involved in rescue of stalled ribosome	IDA IDA: 通过直接分析推断	25578875	GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	25578875	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RQC complex	IDA IDA: 通过直接分析推断	25578875	GOA
located in cytosol	IDA IDA: 通过直接分析推断	25578875	GOA
is active in cytosolic ribosome	IDA IDA: 通过直接分析推断	25578875	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEMF 蛋白结构

FbpA

DUF814

DUF3441

0
200
400
600
800
1000
1076 a.a.

蛋白主名

其他名称

ribosome quality control complex subunit NEMF

New-York Colon 1

关联疾病

疾病名称

别名

Intellectual Developmental Disorder With Speech Delay And Axonal Peripheral Neuropathy

IDDSAPN

Intellectual Developmental Disorder, Speech Delay, Axonal Peripheral Neuropathy

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Axonal Neuropathy

Polymicrogyria, Bilateral Temporooccipital

Bilateral Parasagittal Parieto-Occipital Polymicrogyria	BTOP
Bilateral Temporooccipital Polymicrogyria	Polymicrogyria

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09206	NEMF Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	NEMF	MGD	MGI:1918305
Macaca mulatta	NEMF	VGNC	VGNC:84407
Canis familiaris	NEMF	VGNC	VGNC:43741
Bos taurus	NEMF	VGNC	VGNC:32004
Felis catus	NEMF	VGNC	VGNC:63775
Rattus norvegicus	NEMF	RGD	RGD:2315525

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NEMF - nuclear export mediator factor Gene

关于 NEMF

功能概要

NEMF 基因产物(2)

NEMF 蛋白结构

关联疾病

直系同源

热门区域

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NEMF - nuclear export mediator factor Gene

关于 NEMF

功能概要

NEMF 基因产物(2)

NEMF 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z