2. Gene
  3. OLFM2 - olfactomedin 2 Gene

OLFM2 - olfactomedin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：嗅觉调节素 2

种属: Homo sapiens

同用名: NOE2; OlfC; NOELIN2; NOELIN2_V1

基因 ID: 93145 | 基因类型: protein coding

关于 OLFM2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:9,853,718-9,936,515 (from NCBI)

This gene has 5 transcripts (splice variants), 252 orthologues and 9 paralogues. Biased expression in brain (RPKM 38.1), skin (RPKM 32.4) and 13 other tissues.

功能概要

参与平滑肌细胞分化的正调节。作用于蛋白质分泌的上游或内部。位于细胞质中；胞外区；和核质。 [由基因组资源联盟提供，2022 年 4 月]

Involved in positive regulation of smooth muscle cell differentiation. Acts upstream of or within protein secretion. Located in cytoplasm; extracellular region; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OLFM2 基因产物(3)

mRNA Protein Name
NM_001304347.2 NP_001291276.1 noelin-2 isoform 1
NM_001304348.2 NP_001291277.1 noelin-2 isoform 3
NM_058164.4 NP_477512.1 noelin-2 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25298399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
25298399 GOA
acts upstream of or within protein secretion IDA
IDA: 通过直接分析推断
21228389 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25298399 GOA
located in extracellular region IDA
IDA: 通过直接分析推断
21228389 GOA
located in nucleus IDA
IDA: 通过直接分析推断
25298399 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OLFM2 蛋白结构

Noelin-1

Noelin-1: Neurogenesis glycoprotein (25 - 121)

OLF

OLF: Olfactomedin-like domain (198 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
蛋白主名 其他名称

noelin-2

neuronal olfactomedin related ER localized protein 2

OLFM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OLFM2 O95897 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
种属内
OLFM2 O95897 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
种属内
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
种属内
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Open-Angle Glaucoma

Glaucoma Simplex

Pigmentary Glaucoma

Wide-Angle Glaucoma

Glaucoma, Open-Angle

Open Angle Glaucoma

Glaucoma Open-Angle

Chronic Simple Glaucoma

Coag - [Chronic Open-Angle Glaucoma]

Csg - [Chronic Simple Glaucoma]

Poag - [Primary Open-Angle Glaucoma]

Oag - [Open-Angle Glaucoma]

Chronic Glaucoma

Chronic Open Angle Glaucoma

Simple Glaucoma

Chronic Noncongestive Glaucoma

Ltg - [Low Tension Glaucoma]

Noncongestive Glaucoma

Nonobstructive Glaucoma

Normal Pressure Glaucoma

Primary Low Tension Glaucoma

Low-Tension Glaucoma

Residual Stage Low Tension Glaucoma

Open Cleft Glaucoma
Arteriosclerosis Obliterans
Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09771 OLFM2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus OLFM2 RGD RGD:1309741
Bos taurus OLFM2 VGNC VGNC:32418
Macaca mulatta OLFM2 VGNC VGNC:75417
Mus musculus OLFM2 MGD MGI:3045350
Canis familiaris OLFM2 VGNC VGNC:44113
Felis catus OLFM2 VGNC VGNC:63959
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