BAG2 - BAG cochaperone 2 Gene

中文名称：BAG 辅伴侣 2

种属: Homo sapiens

同用名: BAG-2; dJ417I1.2

关于 BAG2

功能概要

BAG 蛋白与 Hip 竞争结合 Hsc70/HSP70 ATPase 结构域并促进底物释放。所有 BAG 蛋白在 C 末端附近都有一个大约 45 个氨基酸的 BAG 结构域，但它们的 N 末端区域明显不同。预测的 BAG2 蛋白包含 211 个氨基酸。 BAG1、BAG2 和 BAG3 的 BAG 结构域在体外和哺乳动物细胞中与 Hsc70 ATPase 结构域特异性相互作用。所有 3 种蛋白质都以高亲和力结合 Hsc70 的 ATPase 结构域，并以 Hip 可抑制的方式抑制其伴侣活性。[RefSeq 提供，2008 年 7 月]

BAG proteins compete with Hip for binding to the Hsc70/HSP70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 Amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]