2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Glochidiol

Glochidiol 是一种具有口服活性的微管蛋白聚合 (tubulin polymerization) 抑制剂，其 IC50 值为 2.76 μM。Glochidiol 显示抗癌活性。

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Glochidiol Chemical Structure

Glochidiol Chemical Structure

CAS No. : 6610-56-6

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Glochidiol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity[1].

IC50 & Target

IC50: 2.76 μΜ (tubulin polymerization)[1]
体外研究
(In Vitro)

Glochidiol (1-8 μM; 48 h) 对肺癌细胞系显示出强效的抗增殖活性，且呈浓度依赖性[1]。
Glochidiol 通过靶向秋水仙碱结合位点与微管蛋白相互作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glochidiol 相关抗体:

Cell Proliferation Assay[1]

Cell Line: NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6
Concentration: 1, 2, 4 and 8 μM
Incubation Time: 48 h
Result: Showed potent antiproliferative activity against lung cancer cell lines NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6 with IC50 values of 4.12 µM, 2.01 µM, 7.53 µM, 1.62 µM, 4.79 µM, 7.69 µM, 2.36 µM, 6.07 µM and 2.10 µM, respectively.
体内研究
(In Vivo)

Glochidiol (60 mg/kg/day; i.g.; 21 days) 在裸鼠中有效抑制肺癌 HCC-44 异种移植瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice bearing HCC-44 xenografts[1]
Dosage: 60 mg/kg/day
Administration: Intragastric administration for a period of 21 days
Result: Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney.
分子量

442.72

Formula

C30H50O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glochidiol 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glochidiol6610-56-6Microtubule/TubulinMCF-7SF-268NCI-H2087HOP-62NCI-H520HCC-44HARAEPLC-272HNCI-H3122COR-L105Calu-6Inhibitorinhibitorinhibit

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