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GSK180 

目录号: HY-112179
产品使用指南

GSK180 是一种有效的、选择性和竞争性的犬尿氨酸-3-单加氧酶 (KMO) 抑制剂,它是色氨酸代谢中的关键酶,IC50 值约为 6 nM。GSK180 对色氨酸途径上其他酶的作用可忽略。GSK180 可快速改变犬尿氨酸 (kynurenine) 通路代谢物的水平,是探索 KMO 抑制治疗潜力的有效工具。

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GSK180 Chemical Structure

GSK180 Chemical Structure

CAS No. : 1799725-26-0

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Description

GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition[1].

IC50 & Target

IC50: ~6 nM (KMO)[1]

In Vitro

GSK180 inhibits endogenous KMO activity in primary human hepatocytes (IC50=2.6 µM). GSK180 inhibits rat KMO slightly less potently than the human enzyme (IC50=7 µM)[1].

In Vivo

GSK180 is proper for i.v. administration[1].

Molecular Weight

276.07

Formula

C₁₀H₇Cl₂NO₄

CAS No.

1799725-26-0

SMILES

O=C(O)CCN1C(OC2=CC(Cl)=C(Cl)C=C12)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
GSK180
目录号:
HY-112179
需求量:

GSK180

Cat. No.: HY-112179