2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. KMO

KMO (犬尿氨酸-3-单加氧酶)

Kynurenine-3-monooxygenase

Kynurenine-3-monooxygenase (KMO) 是一种在犬尿氨酸途径中起关键作用的酶。它以分子氧和 NADPH 为辅因子，催化犬尿氨酸羟基化为 3 - 羟基犬尿氨酸。这种酶主要在肝脏和大脑中表达。在大脑中，犬尿氨酸途径参与神经递质水平的调节和免疫反应。Kynurenine-3-monooxygenase 活性的失调与多种神经和精神疾病有关，如阿尔茨海默病、帕金森病和抑郁症[1][2][3]。

Kynurenine-3-monooxygenase (KMO) is an enzyme that plays a crucial role in the kynurenine pathway. It catalyzes the hydroxylation of kynurenine to 3-hydroxykynurenine, using molecular oxygen and NADPH as cofactors. This enzyme is mainly expressed in the liver and brain. In the brain, the kynurenine pathway is involved in the regulation of neurotransmitter levels and immune responses. Dysregulation of Kynurenine-3-monooxygenase activity has been implicated in various neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's disease, and depression[1][2][3].

KMO 相关产品 (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12347
    Ro 61-8048 Inhibitor 99.76%
    Ro 61-8048 是口服有效的、选择性的犬尿氨酸 3-羟化酶 (kynurenine 3-hydroxylase) 的抑制剂，其 IC50 值为 37 nM。Ro 61-8048 引起细胞喹啉酸浓度的显著增加。
    Ro 61-8048
  • HY-112179
    GSK180 Inhibitor 99.04%
    GSK180 是一种有效的、选择性和竞争性的犬尿氨酸-3-单加氧酶 (KMO) 抑制剂，它是色氨酸代谢中的关键酶，IC50 值约为 6 nM。GSK180 对色氨酸途径上其他酶的作用可忽略。GSK180 可快速改变犬尿氨酸 (kynurenine) 通路代谢物的水平，是动物模型中探索 KMO 抑制剂的有效工具。
    GSK180
  • HY-15500
    JM6 Inhibitor
    JM6 是一种弱犬尿氨酸 3-单加氧酶 (kynurenine 3-monooxygenase, KMO) 抑制剂，对小鼠 KMO 的 IC50 为 19.85 μM。JM6 可用于阿尔茨海默病研究。
    JM6
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