2. Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase
  4. hDHODH-IN-11

hDHODH-IN-11 是一种有效的人二氢旋转酸脱氢酶 (hDHODH) 抑制剂，其 IC50 值为 7.2 nM。hDHODH-IN-11具有低细胞毒性。hDHODH-IN-11 可用于急性髓系白血病 (AML) 的研究。

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hDHODH-IN-11 Chemical Structure

hDHODH-IN-11 Chemical Structure

CAS No. : 2396653-34-0

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hDHODH-IN-11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hDHODH-IN-11 is a potent human dihydroorotate dehydrogenase (hDHODH) inhibitor with an IC50 value of 7.2 nM. hDHODH-IN-11 has low cytotoxicity. hDHODH-IN-11 can be used in research of acute myeloid leukemia (AML)[1].

IC50 & Target

IC50: 7.2 nM (hDHODH)[1]
体外研究
(In Vitro)

hDHODH-IN-11 (0.1 and 1 μM; 72 h; THP1 and U937 cells) has low cytotoxicity, pro-apoptotic and pro-differentiating abilities[1].
hDHODH-IN-11 (0.1 μM; 72 h; THP1 and MV4-11 cells) with Dipyridamole (HY-B0312) results in synergistic effect and demonstrates a good pro-apoptotic activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hDHODH-IN-11 相关抗体:
体内研究
(In Vivo)

hDHODH-IN-11 (20 mg/kg; i.p.; daily, for 13 d; Balb/c mice with AML xenografts) reduces the leukemic burden and tumor weight[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice with AML xenografts[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; daily, for 13 days
Result: Reduced the leukemic burden and tumor weight.
分子量

401.46

Formula

C24H23N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hDHODH-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hDHODH-IN-112396653-34-0Dihydroorotate DehydrogenaseDHODHlow cytotoxicityacute myeloid leukemiaTHP1U937DipyridamoleInhibitorinhibitorinhibit

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