Heneicosane-d₄₄  (Synonyms: 正二十一烷-d₄₄)

Heneicosane-d₄₄ is the deuterium labeled Heneicosane (HY-W089845). Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs^{[1][2][3][4][5]}.

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物研发过程中定量分析的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

340.85

C₂₁D₄₄

39756-37-1

正二十一烷-d₄₄

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Colin F Funaro, et al. Identification of a queen and king recognition pheromone in the subterranean termite Reticulitermes flavipes. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3888-3893.  [Content Brief]

  [3]. Okechukwu P N. Evaluation of anti-inflammatory, analgesic, antipyretic effect of eicosane, pentadecane, octacosane, and heneicosane. Asian J. Pharamath. Clin. Res, 2020, 13.

  [4]. Boukaew S, et al. Efficacy of volatile compounds from Streptomyces philanthi RL-1-178 as a biofumigant for controlling growth and aflatoxin production of the two aflatoxin-producing fungi on stored soybean seeds. J Appl Microbiol. 2020 Sep;129(3):652-664.  [Content Brief]

  [5]. Prathipkumar S, et al. Biogenic-mediated silver nanoparticles using heneicosane and their enhanced antimicrobial, antiproliferative, sensing capability and photocatalytic potential. Applied Nanoscience, 2023, 13(9): 5839-5849.