2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. HS-131

HS-131 是一种近红外 Hsp90 的染料抑制剂，能够检测原癌基因驱动的乳腺癌，并能识别不同的人类乳腺癌分子亚型。

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HS-131 Chemical Structure

HS-131 Chemical Structure

CAS No. : 2084850-40-6

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HS-131 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers[1].
体外研究
(In Vitro)

HS-131 相关抗体:

Immunofluorescence[1]

Cell Line: Tumor cells.
Concentration: 10 µM.
Incubation Time: 30 min.
Result: Tissues/organs, including eyes, brain, heart, lung, liver, spleen, kidney, gut, urinary bladder and skin, were imaged ex vivo by the IVIS imager machine, an imaging modality that detects IR at 640 nm.
体内研究
(In Vivo)

HS131 (10 nmol/mouse) could label breast cancers with different molecular subtypes, including MCF-7 and T-47D for luminal type, BT474M1 and KPL-4 for HER2+ subtype, MDA-MB-231 and MDA-MB-468 for triple negative subtype were chosen after considering the tumorigenic capacities of breast cancer cell lines in SCID mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID-beige mice bearing human breast cancer xenografts of different molecular subtypes[1].
Dosage: 10 nmol/mouse.
Administration: Injected intravenously.
Result: All breast cancer xenografts with different molecular subtypes showed stronger nIR signals in tumor by intravenous administration of HS131 compared to HS152, and the retention of the nIR signals was detectable even at the 24 h time point in HS131 injected mice.
分子量

1318.68

Formula

C71H95N7O13S2
CAS 号
Emission (Em)

710
Excitation (Ex)

640
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HS-131 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS-1312084850-40-6HS131HS 131HSPHeat shock proteinsbreastcancerdyeMCF-7T-47DInhibitorinhibitorinhibit

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目录号：
HY-122878
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