1. Stem Cell/Wnt TGF-beta/Smad Membrane Transporter/Ion Channel
  2. TGF-beta/Smad Potassium Channel
  3. Hydrochlorothiazid-d2

Hydrochlorothiazid-d2  (Synonyms: HCTZ-d2)

目录号: HY-B0252S 纯度: 98.89%
COA 产品使用指南

Hydrochlorothiazid-d2 是 Hydrochlorothiazide 的氘代物。Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药,可抑制转化 TGF-β/Smad 信号通路。Hydrochlorothiazide 通过打开钙激活钾 (KCA) 通道具有直接的血管松弛作用。Hydrochlorothiazide 改善心脏功能,减少纤维化并具有降压作用。

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Hydrochlorothiazid-d<sub>2</sub> Chemical Structure

Hydrochlorothiazid-d2 Chemical Structure

CAS No. : 1219798-89-6

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Top Publications Citing Use of Products
  • 生物活性

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生物活性

Hydrochlorothiazid-d2 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

299.75

Formula

C7H6D2ClN3O4S2

CAS 号
性状

固体

颜色

White to off-white

中文名称

氢氯噻嗪 d2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Hydrochlorothiazid-d2
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