2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO1-IN-21

IDO1-IN-21 (化合物 10m) 是一种 IDO1 抑制剂 (IC50 = 0.64 μM)。IDO1-IN-21 能有效抑制小鼠体内肿瘤的生长。

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IDO1-IN-21 Chemical Structure

IDO1-IN-21 Chemical Structure

CAS No. : 2892432-98-1

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IDO1-IN-21 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC50 = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice[1].

IC50 & Target[1]

IDO1

0.64 μM (IC50)

体外研究
(In Vitro)

IDO1-IN-21 (0-50 μM; 48 h) 抑制 SW480 细胞活力，其 IC50 值为 28.64 μM[1]。
IDO1-IN-21 (0-10 μM; 48 h) 抑制 HeLa 细胞的 IDO1，其 IC50 值为 1.04 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IDO1-IN-21 相关抗体:

Cell Viability Assay[1]

Cell Line: SW480 cells
Concentration: 0-50 μM
Incubation Time: 48 h
Result: Surpressed viability of SW480 cells (IC50 = 28.64 μM).
体内研究
(In Vivo)

IDO1-IN-21 (50, 100 mg/kg; i.p.; every three day for 21 consecutive days) 抑制 CT26 荷瘤小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 tumor-bearing mice[1].
Dosage: 50, 100 mg/kg
Administration: Intraperitoneal administration; every three day for 21 consecutive days.
Result: Led to significant suppression of tumor growth.
分子量

479.45

Formula

C21H19F2N3O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDO1-IN-21 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1-IN-212892432-98-1Indoleamine 2,3-Dioxygenase (IDO)tumorcancerSW480 cellsHeLa cellsInhibitorinhibitorinhibit

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产品名称：
IDO1-IN-21
目录号：
HY-149227
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