2. Anti-infection Metabolic Enzyme/Protease
  3. Influenza Virus Glucosidase
  4. IHVR-17028

IHVR-17028 是一种有效的广谱的抗病毒活性分子。 IHVR-17028 对 BVDV、TCRV 和 DENV 的抗病毒活性分别为 EC50 0.4 μM、0.26 μM、0.3 μM。IHVR-17028 是一种有效的ER α-葡萄糖苷酶I (α-glucosidase I) 抑制剂，其 IC50 为 0.24 μM。IHVR-17028 可用于传染病研究。

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IHVR-17028 Chemical Structure

IHVR-17028 Chemical Structure

CAS No. : 1428247-78-2

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规格 价格 是否有货 数量
1 mg ￥3995
1 周
5 mg   询价  
10 mg   询价  

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Customer Review

IHVR-17028 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research[1][2].

体外研究
(In Vitro)

In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC50 values of all >500 μM in?MDBK, Huh7.5 or BHK cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IHVR-17028 相关抗体:
体内研究
(In Vivo)

In Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a Cmax?value of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T1/2 value is 0.88 hour after iv. adminstration[1].
IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection[1]
Dosage: 50 mg/kg
Administration: Treatment 1 day prior to virus challenging
Result: Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.
Animal Model: C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV[1]
Dosage: 25 mg/kg
Administration: Twice daily at 12 h interval; starting 4 h post infection for 10 days
Result: Inhibited EBOV infection in mice.
分子量

428.61

Formula

C23H44N2O5
CAS 号
性状

油状物

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

IHVR-17028 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IHVR-170281428247-78-2IHVR17028IHVR 17028Influenza VirusGlucosidaseviraltacaribe virusDENVBVDVdiarrhea virusMDBKHuh7.5BHKInhibitorinhibitorinhibit

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产品名称：
IHVR-17028
目录号：
HY-139663
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