1. NF-κB
  2. NF-κB
  3. IKKγ NBD Inhibitory Peptide

IKKγ NBD 抑制肽是一种高度特异性的 NF-κB 抑制剂。IKKγ NBD 抑制肽通过阻断 IKKγ/NEMO 结合域 (NBD) 与 IKKα 和 IKKβ 之间的相互作用,而阻断 TNF-α 诱导的 NF-κB 激活。IKKγ NBD 抑制肽可显著降低炎症、改善脑缺血所致的神经功能缺损。

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Custom Peptide Synthesis

IKKγ NBD Inhibitory Peptide Chemical Structure

IKKγ NBD Inhibitory Peptide Chemical Structure

CAS No. : 372146-18-4

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IKKγ NBD Inhibitory Peptide 的其他形式现货产品:

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Other Forms of IKKγ NBD Inhibitory Peptide:

查看 NF-κB 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits[1][2][3].

体外研究
(In Vitro)

在一个典型途径中,NF-κB 的激活依赖于 IKK 复合体的活性,该复合体由三个亚基 (IKKκ、IKKβ 和 IKKγ/NEMO) 组成,因此,KKγ NBD 抑制肽抑制 TNF-α 诱导的 NF- kb激活[2]
IKKγ NBD 抑制肽 (10 μM; 90 min) 能够阻碍 Doxorubicin (HY-15142A) 诱导 (15 μM;4 h) 的 BT-474 细胞中 p65 磷酸化[2]
IKKγ NBD 抑制肽 (10 μM; 48 h) 对BT-474细胞活力有轻微抑制作用,而对 Doxorubicin 的效力有增强作用[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

IKKγ NBD 抑制肽 (40 μg/4 μL;ICV; 单剂量; 于 MCAO 诱导前 2 h) 在大鼠模型脑中动脉闭塞 (MCAO) 模型中显示出神经保护作用,减少 DNA 碎片化,其机制可能与减少缺血损伤后的炎症有关[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (255 g) with middle cerebral artery occlusion (MCAO)[3]
Dosage: 40 μg/4 μL
Administration: Intracerebroventricular injection; 2 h before MCAO induction
Result: Significantly reduced striatal IL-1b level in IKK-NBD peptide treated rats.
Also resulted in reduced staining of microglial OX-42 and protection of BBB from ischemic insult.
分子量

3693.30

Formula

C170H259N49O42S1

CAS 号
Sequence Shortening

DRQIKIWFQNRRMKWKKTALDWSWLQTE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

IKKγ NBD Inhibitory Peptide 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
IKKγ NBD Inhibitory Peptide
目录号:
HY-P1847
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