2. Inhibitory Antibodies
  3. Inclacumab

Inclacumab  (Synonyms: Anti-Human selectin P Recombinant Antibody)

目录号: HY-P99263 纯度: 99.80%
COA

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Inclacumab (Anti-Human selectin P Recombinant Antibody) 是人源的 IgG4 单克隆抗体选择性的靶向 P-selectin，Kd 值为 9.9 nM。Inclacumab 抑制 P-selectin 糖蛋白配体 1 (PSGL-1) 模拟肽与 P-selectin 结合，IC50 值为1.9 μg/mL。Inclacumab 强烈的抑制细胞黏附。

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Inclacumab Chemical Structure

Inclacumab Chemical Structure

CAS No. : 1256258-86-2

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Inclacumab 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion[1][2][3].

体外研究
(In Vitro)

Inclacumab (0.4-40 μg/mL; 5 min) significantly reduces flow adhesion of P-Selectin with Whole Blood (WB) and isolated White Blood Cell (I-WBC) and shows a more stronger effect on isolated white cells[1].
Inclacumab shows great binding affinity to P-selectin with a Kd value of 9.9 nM[2].
Inclacumab inhibits PSGL-1 mimetic peptide binding with P-selectin with an IC50 value of 1.9 µg/mL[2].
Inclacumab blocks the adhesion of PSGL-1 expressing cells to an immobilized P-selectin with an IC50 value of 430 ng/mL[2].
Inclacumab (0-100 μg/mL; 5min) dose-dependently inhibits thrombin receptor-activating peptide (TRAP)-induced platelet-leukocyte aggregates (PLA) levels with an IC50 value of 1.4 μg/mL[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Inclacumab 相关抗体:
体内研究
(In Vivo)

Inclacumab (4 mg/kg; s.c. once) reduces TRAP- and ADP-induced PLA levels in cynomolgus monkeys[3].
Inclacumab (2-50 mg/kg; i.v.; once a week for 13 weeks) inhibits TRAP induced PLA levels in cynomolgus monkeys[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[3]
Dosage: 4 mg/kg
Administration: Subcutaneous injection; 4 mg/kg; once
Result: Significantly reduced TRAP-induced PLA levels from 25% to 6% and supressed PLA formation ≥80% for at least 28 days post treatment. Remained plasma concentrations >20 μg/mL during post treatment for 28 days. Significantly inhibited the formation of ADP (10 μM)-induced PLAs.
Animal Model: Cynomolgus monkeys[3]
Dosage: 2, 10, and 50 mg/kg
Administration: Intravenous injection; once daily; for 13 weeks
Result: Inhibited TRAP-induced PLA and remained concentrations at all three dose levels are higher than 20 μg/mL. Persisted the full inhibition of PLA formation between dosing period.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.80%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

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  • Do most proteins show cross-species activity?

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Keywords:

Inclacumab1256258-86-2Anti-Human selectin P Recombinant AntibodyhumanizedmonoclonalIgG4antibodyPSGL-1cell adhesionI-WBCWBTRAPPLAcynomolgus monkeysInhibitorinhibitorinhibit

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