1. Apoptosis
  2. TNF Receptor
  3. Infliximab

Infliximab (Synonyms: Avakine; CT-P13)

目录号: HY-P9970
产品使用指南

Infliximab (Avakine) 是一种与 TNF-α 特异性结合的嵌合单克隆 IgG1 抗体。Infliximab 可阻止 TNF-α 与 TNF-α 受体 1 (TNFR1) 和 TNFR2 的相互作用。Infliximab 可用于自身免疫,慢性炎症性疾病和糖尿病神经病变的研究。

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Custom Peptide Synthesis

Infliximab Chemical Structure

Infliximab Chemical Structure

CAS No. : 170277-31-3

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Description

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research[1][2].

IC50 & Target[1]

TNF-α

 

In Vitro

TNF-α-treated adipocytes shows a significant 64% decrease in insulin-stimulated glucose uptake, whereas Infliximab (10 ng/mL) reverses TNF-α actions by significantly improving glucose incorporation in 3T3L1 adipocytes. Infliximab restores phosphorylation of substrate-2 and AKT by attenuating protein-tyrosine phosphatase 1B (PTP1B) activation. Infliximab ameliorates TNF-α-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring the insulin signalling pathway via PTP1B inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A single injection of Infliximab (10 μg/g in 100 μl saline/dose ip) in diabetic TNF-α+/+) mice leads to suppression of the increased serum TNF-α and amelioration of the electrophysiological and biochemical deficits for at least 4 weeks. The increased TNF-α mRNA expression in diabetic dorsal root ganglion is also attenuated by Infliximab[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.

170277-31-3

中文名称

英夫利昔单抗

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

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Keywords:

InfliximabAvakine CT-P13TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNFR2TNFR1anti-TNF-αmonoclonalautoimmuneanti-inflammatoryPTP1BdiabeticneuropathyInhibitorinhibitorinhibit

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产品名称:
Infliximab
目录号:
HY-P9970
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