2. Apoptosis Anti-infection
  3. TNF Receptor Bacterial
  4. Infliximab

Infliximab  (Synonyms: Avakine; CT-P13)

目录号: HY-P9970 纯度: 90.30%
COA

摩尔计算器

Infliximab (Avakine) 是一种与 TNF-α 特异性结合的嵌合单克隆 IgG1 抗体。Infliximab 可阻止 TNF-α 与 TNF-α 受体 1 (TNFR1) 和 TNFR2 的相互作用。Infliximab 可用于自身免疫，慢性炎症性疾病和糖尿病神经病变的研究。

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Infliximab Chemical Structure

Infliximab Chemical Structure

CAS No. : 170277-31-3

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1 mg ￥1200
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5 mg ￥3000
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10 mg ￥4650
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25 mg ￥7363
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Customer Review

Infliximab 相关抗体

Top Publications Citing Use of Products

    Infliximab purchased from MCE. Usage Cited in: Int Immunopharmacol. 2023 May.

    Infliximab (IFX; 10 mg/kg; i.p.; single) significantly increases the number of RGCs in mice.

    Infliximab purchased from MCE. Usage Cited in: Int Immunopharmacol. 2023 May.

    Infliximab (IFX; 10 mg/kg; i.p.; single) decreases the p-p38/p38 level in NMDA-induced RGC injury mouse retinas.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research[1][2].

    体外研究
    (In Vitro)

    TNF-α 处理的脂肪细胞显示胰岛素刺激的葡萄糖摄取显著降低 64%，而 Infliximab (10 ng/mL) 通过显著改善 3T3L1 脂肪细胞中的葡萄糖掺入来逆转 TNF-α 作用。Infliximab 通过减弱蛋白酪氨酸磷酸酶 1B (PTP1B) 激活来恢复底物 2 和 AKT 的磷酸化。Infliximab 通过抑制 PTP1B 恢复胰岛素信号通路，从而在体外改善 3T3L1 脂肪细胞中 TNF-α 诱导的胰岛素抵抗[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Infliximab 相关抗体:
    体内研究
    (In Vivo)

    在糖尿病 TNF-α+/+) 小鼠中单次注射 Infliximab (100 ul 盐水中的 10 μg/g/剂量 ip) 可抑制血清 TNF-α 升高并改善电生理和生化缺陷至少 4 周。Infliximab 也减弱了糖尿病背根神经节中增加的 TNF-α mRNA 表达[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    英夫利昔单抗
    运输条件

    Shipping with dry ice.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料

    纯度: 90.30%

    COA (172 KB)

    抗体抑制剂使用指南 (1152 KB)
    参考文献

    Infliximab 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Infliximab170277-31-3Avakine CT-P13英夫利昔单抗TNF ReceptorBacterialTumor Necrosis Factor ReceptorTNFRTNFR2TNFR1anti-TNF-αmonoclonalautoimmuneanti-inflammatoryPTP1BdiabeticneuropathyInhibitorinhibitorinhibit

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