2. Anti-infection
  3. Influenza Virus
  4. Influenza A virus-IN-8

Influenza A virus-IN-8  (Synonyms: S5)

目录号: HY-149034
产品使用指南

摩尔计算器

Influenza A virus-IN-8 (S5) 是一种无细胞毒性的大环肽。Influenza A virus-IN-8 也是一种有效的甲型流感病毒 (IAV) 抑制剂 (具有较好的蛋白酶稳定性)，其对 H1 和 H5 变体的 IC50 值分别为 6.7 和 6.6 nM。Influenza A virus-IN-8 能与 HA 茎中的一个保守区域结合，对 H1 显示了良好的亲和性，其 Kd 值为 1.0 nM。

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Custom Peptide Synthesis

Influenza A virus-IN-8 Chemical Structure

Influenza A virus-IN-8 Chemical Structure

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Influenza A virus-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM[1].

体外研究
(In Vitro)

Influenza A virus-IN-8 (5 μM; 72 h) does not affect viability of HeLa and MDCKI cells[1].
Influenza A virus-IN-8 (5 μM; 24 h) shows neutralizing effect on H1N1pdm09 and H5N1 in a dose-dependent manner[1].
Influenza A virus-IN-8 (5 nM; 2 h) binds to a conserved region in the HA stem with Kd of 1.0 nM for H1 variants[1].
Influenza A virus-IN-8 (5 μM; 1 h) inhibits HA fusion activity during entry by stabilizing the prefusion conformation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza A virus-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa and MDCKI cells
Concentration: 5 μM
Incubation Time: 72 h
Result: Exhibited no detectable cytotoxicity in HeLa and MDCKI cells.

Cell Viability Assay[1]

Cell Line: MDCK-II cells (ATCC; H1N1pdm09 and H5N1 infection)
Concentration: 5 µM
Incubation Time: 24 h
Result: Againsted H1N1pdm09 and H5N1 in MDCK-II cells in a dose-dependent manner.

Cell Viability Assay[1]

Cell Line: MDCKI cells (transfected the pFRT expression plasmids encoding the full-length H1)
Concentration: 5 nM
Incubation Time: 2 h
Result: Decreased the staining of full length, membrane-bound H1 HA expressed on the surface of MDCK cells, and binded to a conserved region in the HA stem with Kd of 1.0 nM.

Cell Viability Assay[1]

Cell Line: MDCKI cells
Concentration: 5 µM
Incubation Time: 1 h
Result: Exhibited aeffect on surpressing HA fusion activity during entry by stabilizing the prefusion conformation in MDCKI cells.
Clinical Trial
分子量

2200.48

Formula

C104H142N28O24S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Influenza A virus-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza A virus-IN-8S5S 5S-5Influenza VirusvaccineHAinfluenza A virusesH1H5IAVHeLaMDCKIMDCK-IIInhibitorinhibitorinhibit

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