2. Anti-infection
  3. Influenza Virus
  4. Influenza A virus-IN-8

Influenza A virus-IN-8  (Synonyms: S5)

目录号: HY-149034
产品使用指南 技术支持

Influenza A virus-IN-8 (S5) 是一种无细胞毒性的大环肽。Influenza A virus-IN-8 也是一种有效的甲型流感病毒 (IAV) 抑制剂 (具有较好的蛋白酶稳定性)，其对 H1 和 H5 变体的 IC50 值分别为 6.7 和 6.6 nM。Influenza A virus-IN-8 能与 HA 茎中的一个保守区域结合，对 H1 显示了良好的亲和性，其 Kd 值为 1.0 nM。

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Custom Peptide Synthesis

Influenza A virus-IN-8 Chemical Structure

Influenza A virus-IN-8 Chemical Structure

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Influenza A virus-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM[1].

体外研究
(In Vitro)

Influenza A virus-IN-8 (5 μM; 72 h) does not affect viability of HeLa and MDCKI cells[1].
Influenza A virus-IN-8 (5 μM; 24 h) shows neutralizing effect on H1N1pdm09 and H5N1 in a dose-dependent manner[1].
Influenza A virus-IN-8 (5 nM; 2 h) binds to a conserved region in the HA stem with Kd of 1.0 nM for H1 variants[1].
Influenza A virus-IN-8 (5 μM; 1 h) inhibits HA fusion activity during entry by stabilizing the prefusion conformation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza A virus-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa and MDCKI cells
Concentration: 5 μM
Incubation Time: 72 h
Result: Exhibited no detectable cytotoxicity in HeLa and MDCKI cells.

Cell Viability Assay[1]

Cell Line: MDCK-II cells (ATCC; H1N1pdm09 and H5N1 infection)
Concentration: 5 µM
Incubation Time: 24 h
Result: Againsted H1N1pdm09 and H5N1 in MDCK-II cells in a dose-dependent manner.

Cell Viability Assay[1]

Cell Line: MDCKI cells (transfected the pFRT expression plasmids encoding the full-length H1)
Concentration: 5 nM
Incubation Time: 2 h
Result: Decreased the staining of full length, membrane-bound H1 HA expressed on the surface of MDCK cells, and binded to a conserved region in the HA stem with Kd of 1.0 nM.

Cell Viability Assay[1]

Cell Line: MDCKI cells
Concentration: 5 µM
Incubation Time: 1 h
Result: Exhibited aeffect on surpressing HA fusion activity during entry by stabilizing the prefusion conformation in MDCKI cells.
Clinical Trial
分子量

2200.48

同用名

S5

Formula

C104H142N28O24S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Influenza A virus-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza A virus-IN-8S5S 5S-5Influenza VirusvaccineHAinfluenza A virusesH1H5IAVHeLaMDCKIMDCK-IIInhibitorinhibitorinhibit

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