2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. ING-1

ING-1 (heMab) 是一种高亲和力的人源化抗上皮细胞粘附分子 (Ep-CAM) 单克隆抗体。ING-1 是一种介导 Ca2+ 的跨膜糖蛋白 (transmembrane glycoprotein)。ING-1 与肿瘤细胞上的 Ep-CAM 结合，具有强大的体外活性，可靶向并抑制小鼠癌症模型中肿瘤的生长和转移。ING-1 可用于乳腺癌、结直肠癌、肺癌等癌症的研究。

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ING-1

ING-1 Chemical Structure

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ING-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ING-1 (heMab) is a high-affinity humanized monoclonal antibody against epithelial cell adhesion molecule (Ep-CAM). ING-1 is a transmembrane glycoprotein mediating Ca2+. ING-1 binds to Ep-CAM on tumor cells and exhibits potent in vitro activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

EpCAM/TROP1/CD326
体外研究
(In Vitro)

ING-1 (0.1-10000 nM，4℃，5 小时) 与放射性标记的嵌合 ING-1 竞争结合 HT-29 人细胞中的 Ep-CAM，Kd 值为 2 至 5 nM[1]。
ING-1 (37℃，4 小时) 在 ADCC 和 CDC 活性测定中引起 51Cr 标记的 BT-20、MCF-7、HT-29、CACO-2、NCI-H1568、PC-3、HPAF-II 细胞的浓度依赖性裂解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ING-1 相关抗体:
体内研究
(In Vivo)

ING-1 (0.1-1.0 mg/kg，静脉注射，每周两次，共三周) 可减小 HT-29 和 PC-3 异种移植裸鼠模型中的肿瘤大小和转移[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HT-29 xenograft (3x106/1.5x107) nude mice (20-25 g) model[1][2]
Dosage: 0.1, 0.3, or 1 mg/kg
Administration: i.v., one/two doses per week, 3 weeks
Result: Resulted in a dose-dependent reduction in tumor size relative to control, resulted in a 64% reduction in tumor size at the end of the experiment at 1 mg/kg.
Eliminated visible tumor nodules in body cavities of some animals, reduced tumor metastases on lung surfaces, resulted in 86% reduction of the average number of metastases at 1 mg/kg.
Inhibited micrometastases formation in Lung Tissues, reduced the average number of micrometastasis foci by 91% at 1 mg/kg.
Animal Model: PC-3 xenograft (5x106) nude mice (20-25 g) model[1]
Dosage: 0.1, 0.3, or 1 mg/kg
Administration: i.v., two doses per week, 3 weeks
Result: Resulted in a dose-dependent reduction in tumor size relative to control, resulted in a 71% reduction in tumor size at the end of the experiment at 1 mg/kg.
基因 ID

4072  [NCBI]

Accession
靶点

EpCAM/TROP1/CD326
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ING-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ING-1heMabING1ING 1Transmembrane Glycoproteinmonoclonal antibodybreast cancerlung cancercolorectal cancerBT-20 cellsMCF-7 cellsHT-29 cellsCACO-2 cellsNCI-H1568 cellsPC-3 cellsHPAF-II cellsInhibitorinhibitorinhibit

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