Kurarinol  (Synonyms: 苦参醇)

Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase^[1].

IC50: 0.1 μM (mushroom tyrosinase)^[1]

Kurarinol manifests relatively low cytotoxic activity (EC₅₀>30 μM)^[1].
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism^[1].
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduces serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

456.53

C₂₆H₃₂O₇

855746-98-4

苦参醇

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8.  [Content Brief]

  [2]. Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65.  [Content Brief]

  [3]. Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8.  [Content Brief]