2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel Sodium Channel
  4. Kurtoxin

Kurtoxin 是一种选择性 Cav3 (T-type) 电压门控 Ca2+ 通道门控抑制剂，对 Cav3.1 (α1G T-type) Ca2+ 通道的 < b>Kd 为 15 nM。Kurtoxin 可以与中枢和外周神经元的天然高阈值 L 型、N 型和 P 型 Ca2+ 通道高度亲和地相互作用。Kurtoxin 还与电压门控 Na+ 通道表现出交叉反应性。

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Custom Peptide Synthesis

Kurtoxin Chemical Structure

Kurtoxin Chemical Structure

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Kurtoxin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor with a Kd of 15 nM for Cav3.1 (α1G T-type) Ca2+ channel. Kurtoxin can interact with high affinity with native neuronal high-threshold L-type, N-type, and P-type Ca2+ channels in central and peripheral neurons. Kurtoxin also shows cross-reactivity with voltage-gated Na+ channel[1].

IC50 & Target

Kd: 15 nM (Cav3.1 (α1G T-type) Ca2+ channel)[1]
分子量

7386.36

Formula

C324H478N94O90S8
Sequence

Lys-Ile-Asp-Gly-Tyr-Pro-Val-Asp-Tyr-Trp-Asn-Cys-Lys-Arg-Ile-Cys-Trp-Tyr-Asn-Asn-Lys-Tyr-Cys-Asn-Asp-Leu-Cys-Lys-Gly-Leu-Lys-Ala-Asp-Ser-Gly-Tyr-Cys-Trp-Gly-Trp-Thr-Leu-Ser-Cys-Tyr-Cys-Gln-Gly-Leu-Pro-Asp-Asn-Ala-Arg-Ile-Lys-Arg-Ser-Gly-Arg-Cys-Arg-Ala (Disulfide bridge: Cys12-Cys61,Cys16-Cys37,Cys23-Cys44,Cys27-Cys46)
Sequence Shortening

KIDGYPVDYWNCKRICWYNNKYCNDLCKGLKADSGYCWGWTLSCYCQGLPDNARIKRSGRCRA (Disulfide bridge: Cys12-Cys61,Cys16-Cys37,Cys23-Cys44,Cys27-Cys46)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kurtoxin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KurtoxinCalcium ChannelSodium ChannelCa2+ channelsCa channelsNa channelsNa+ channelsParabuthus transvaalicusL-typeN-typeP-typeα1G T-typeInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P5869
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