2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. L-689560

L-689560 是一种有效的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂，抑制 GluN1 甘氨酸结合位点。L-689560 在广泛用作结合研究中的放射性标记配体，也用来研究 NMDA 受体在正常神经系统过程以及疾病中的作用。

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L-689560 Chemical Structure

L-689560 Chemical Structure

CAS No. : 139051-78-8

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规格 价格 是否有货 数量
1 mg ￥2342
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5 mg ￥6150
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L-689560 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2].

体外研究
(In Vitro)

L-689560 is a 2-carboxytetrahydroquinoline antagonist[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-689560 相关抗体:
体内研究
(In Vivo)

L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model[1]
Dosage: 1 mg/kg
Administration: IP
Result: Significantly reduced the neuroprotective effect of glycine after glycine receptors.
分子量

380.23

Formula

C17H15Cl2N3O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

L-689560 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-689560139051-78-8L689560L 689560iGluRIonotropic glutamate receptorsN-methyl-D-aspartateNMDAGluN1glycineradiolabeledligandneurological2-carboxytetrahydroquinolineInhibitorinhibitorinhibit

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目录号：
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