Lecanemab (Mouse IGG2a)  (Synonyms: Mab158)

Lecanemab (Mouse IGG2a) (Mab158) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IGG2a sequence. Lecanemab (Mouse IGG2a) almost abolishes Aβ accumulation in astrocytes and rescues neurons from Aβ-induced cell death. Lecanemab (Mouse IGG2a) holds promise for research in the field of Alzheimer's disease^[1][2][3].

Mouse IgG2a kappa

Mouse IgG2a kappa, Isotype Control

Human

Amyloid Beta/Aβ

Lecanemab (Mouse IGG2a) (13 nM，24 小时) 在来源于胚胎小鼠皮层的星形胶质细胞、神经元和少突胶质细胞的共培养体系中几乎完全消除星形胶质细胞中的 Aβ 积累，并拯救神经元免受 Aβ 诱导的细胞死亡^[1]。
Lecanemab (Mouse IGG2a) (13 nM，24 小时) 在预先用蛋白酶体抑制剂 MG-132 (HY-13259) 或溶酶体抑制剂 Bafilomycin (HY-100558) 处理的共培养体系中仍能发挥降低 Aβ 的效果^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lecanemab (Mouse IGG2a) (作为 [¹²⁴I]RmAb158-scFv8D3) 在 tg-ArcSwe 和 tg-Swe 小鼠的大脑皮层、海马和丘脑中产生显著的滞留信号，其信号强度与 [¹²⁴I]RmAb3D6-scFv8D3 相当^[2]。
Lecanemab (Mouse IGG2a) 在 tg-UppSwe 小鼠脑切片中显示出非常微弱的染色，而在 tg-ArcSwe 和 tg-Swe 小鼠脑切片中显示出与 Aβ40+Aβ42 阳性区域重叠的强染色^[2]。
Lecanemab (Mouse IGG2a) (10 mg/kg, 腹腔注射, 每周一次, 持续 4/13 周) 在携带 APP Arctic 突变的 tg-ArcSwe 转基因小鼠模型中显示出显著的抗阿尔茨海默病 (AD) 病理作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

351  [NCBI]

P05067

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

147.71 kDa

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Söllvander S, et al. The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death. J Neuroinflammation. 2018 Mar 28;15(1):98.  [Content Brief]

  [2]. Rizoska B, et al. Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice. Mol Cell Neurosci. 2024 Sep;130:103950.  [Content Brief]

  [3]. Tucker S, et al. The murine version of BAN2401 (mAb158) selectively reduces amyloid-β protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice. J Alzheimers Dis. 2015;43(2):575-88.  [Content Brief]