2. Apoptosis
  3. TNF Receptor
  4. Lenercept

Lenercept  (Synonyms: p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1)

目录号: HY-P99692

摩尔计算器

Lenercept (Ro 45-2081) 是一种重组融合蛋白，由可溶性 TNF-receptor (p55) 组成，连接到人 IgG1 的 Fc 部分。

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Lenercept Chemical Structure

Lenercept Chemical Structure

CAS No. : 156679-34-4

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Lenercept 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble TNF-receptor (p55) linked to the Fc portion of human IgG1[1].

IC50 & Target

TNFR[1]
体外研究
(In Vitro)

Lenercept (TNFR-IgG) 在放线菌素 D (HY-17559) 处理的小鼠 L-M 细胞中阻断 TNF-α 和 TNF-β 的细胞溶解作用，IC50 分别为 0.5 μg/mL 和 1.5 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lenercept 相关抗体:
体内研究
(In Vivo)

Lenercept (Ro 45-2081) 抑制 Sephadex 诱导的大鼠肺损伤[1]。
Lenercept (TNFR-IgG; 0.8-20 μg/mouse; i.v.; once) 当内毒素激发之前或之后不久给药时，可以预防或显著延迟内毒素诱导的小鼠致死率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 1 and 3 mg/kg
Administration: Intraperitoneal injection, 1 h before administration of Sephadex for the 24 h study or 1 h before and at 24 and 48 h after Sephadex for the 72 h study
Result: Inhibited the neutrophilia at 24 h after Sephadex. At 72 h after Sephadex, significantly reduced the neutrophil influx into bronchoalveolar lavage fluid (BALF) but had no inhibitory effect on eosinophil number.
Animal Model: 6- to 8-week-old female BALB/c mice, septic shock model[2]
Dosage: 0.8, 4 or 20 μg/mouse
Administration: IV, single dose
Result: Injection 0.5 h prior to Salmonella abortus-derived endotoxin (LD100 dose) administration prevented lethality at a dose of 20 μg per mouse and provided partial protection at lower doses. Injection of 10 μg per mouse provided significant protection 0.5 h before, 0.5 h after, or 1 h after endotoxin injection but little protection 2 h after endotoxin injection.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lenercept 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenercept156679-34-4p55TNF-R:Ig Ro 45-2081 TNFR55-IgG1TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNF-αTNF-βL-M cellBALB/c miceInhibitorinhibitorinhibit

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