Lifastuzumab  (Synonyms: 利法妥珠单抗)

Lifastuzumab is a humanized anti-NaPi2b IgG1 monoclonal antibody. Lifastuzumab can be coupled with monomethyl auristatin E (MMAE) (HY-15162) through ADC Linker to form an antibody-drug conjugate (ADC) Lifastuzumab vedotin (HY-P99705) with anticancer activity. Lifastuzumab vedotin can be studied in research for non-small cell lung cancer and ovarian cancer. Recommend Isotype Control: Human IgG1 kappa, Isotype Control (HY-P99001)^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

NaPi2b/SLC34A2

Lifastuzumab 可与 MMAE (HY-15162) 通过 ADC 连接子偶联，形成具有抗癌活性的抗体-药物偶联物 (ADC) Lifastuzumab vedotin (HY-P99705)^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

10568  [NCBI]

O95436

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

145.66 kDa

1615697-16-9

液体

Colorless to light yellow

利法妥珠单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Immobilized SLC34A2 Protein can bind Lifastuzumab.The EC₅₀ for this effect is 11.69 ng/mL.

• [1]. Banerjee S, et al. Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study. Ann Oncol. 2018 Apr 1;29(4):917-923.  [Content Brief]

  [2]. David E. Gerber, et al., Phase Ia Study of Anti-NaPi2b Antibody–Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non–Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer. Clin Cancer Res 15 January 2020; 26 (2): 364–372.