2. MAPK/ERK Pathway Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. p38 MAPK JNK Apoptosis Reactive Oxygen Species
  4. LL-Z1640-4

LL-Z1640-4 是一种有效的 p38/JNK 信号抑制剂。 LL-Z1640-4 显著降低了 MLK4 siRNA 转染的 HCC 细胞中 p38 和 JNK 的活化。 LL-Z1640-4 显著减弱 MLK4 敲低引起的 ROS 的产生。 LL-Z1640-4 显著降低转染 siMLK4 的 HCC 细胞中凋亡 (apoptotic) 细胞。

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LL-Z1640-4 Chemical Structure

LL-Z1640-4 Chemical Structure

CAS No. : 66018-41-5

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规格 价格 是否有货 数量
1 mg ￥2830
3 - 4 周
5 mg   询价  
10 mg   询价  

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LL-Z1640-4 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4[1][2].

体外研究
(In Vitro)

LL-Z1640-4 markedly restores the number of cells in migration and invasion decreased by siMLK4, and significantly up-regulates expression of MMP2 and Vimentin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LL-Z1640-4 相关抗体:
分子量

364.39

Formula

C19H24O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LL-Z1640-4 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LL-Z1640-466018-41-5p38 MAPKJNKApoptosisReactive Oxygen Speciesc-Jun N-terminal kinaseHCC cellssiMLK4MLK4HepG2BEL-7404 cellsMMP2Hepatocellular carcinomaInhibitorinhibitorinhibit

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