1. Protein Tyrosine Kinase/RTK Apoptosis Antibody-drug Conjugate/ADC Related
  2. IGF-1R Apoptosis ADC Antibody
  3. Lonigutamab

Lonigutamab  (Synonyms: hz208F2-4)

目录号: HY-P99712 纯度: 95.00%
COA 技术支持

Lonigutamab (hz208F2-4) 是一种人源化抗-IGF-1R 单克隆抗体,常作为抗体-药物偶联物 (ADC) 的靶向载体。Lonigutamab 诱导 IGF-1R 过表达肿瘤细胞发生 G2-M 期细胞周期阻滞,并增加细胞凋亡 (apoptosis)。Lonigutamab 在 IGF-1R 过表达的异种移植模型中显示出强大的抗肿瘤效果。Lonigutamab 可用于研究 IGF-1R 过表达的实体瘤和甲状腺眼病。

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CAS No. : 2362015-67-4

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规格 价格 是否有货 数量
1 mg ¥3000
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lonigutamab (hz208F2-4) is a humanized anti-IGF-1R monoclonal antibody, serveing as a targeting vector for antibody-drug conjugates (ADCs). Lonigutamab causes G2-M phase cell cycle arrest and increases apoptosis in IGF-1R-overexpressing tumor cells. Lonigutamab demonstrates potent antitumor efficacy in IGF-1R-overexpressing xenograft models. Lonigutamab can be used for the study of Solid tumors with overexpression of IGF-1R and thyroid eye diseases[1]sup>[2].

同型

Human IgG1 kappa

推荐同型对照抗体
反应种属

Human

IC50 & Target

IGF1R/CD221

体外研究
(In Vitro)

Lonigutamab (0-10 μg/mL, 6 天) 在 IGF-1R 高表达的 MCF-7 (IC50 = 5.1×10-11 mol/L) 和 NCI-H2122 (IC50 = 6.25×10-10 mol/L) 细胞中诱导近 100% 的细胞死亡[1]
Lonigutamab (10 μg/mL, 10-120 分钟) 在 MCF-7 细胞中显示出快速内化,并与溶酶体共定位[1]
Lonigutamab (10 μg/mL, 72 小时) 在 MCF-7 细胞中引起大量的 M 期细胞周期阻滞,并显著增加凋亡和晚期坏死细胞的比例[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Lonigutamab (3 mg/kg, 静脉注射, 每四天一次,共 4 个周期) 显著抑制 MCF-7 乳腺癌、NCI-H2122 肺癌、CaoV3 卵巢癌、Hs746t 和 SBC5 肺癌异种移植模型中的肿瘤生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCF-7, CaoV3, SBC5, NCI-H2122 and Hs746t cells were subcutaneously implanted into the flanks of 7-week-old female Swiss nude mice[1]
Dosage: 3 mg/kg
Administration: i.v., once for four days, 4 cycles
Result: Achieved tumor growth inhibition.
Showed no significant changes in body weight.
Clinical Trial
基因 ID

3480  [NCBI]

Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

145.12 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Biological Activity
  • Flow cytometric analysis of 1X106 MCF-7 cells with Lonigutamab (HY-P99712, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Lonigutamab
目录号:
HY-P99712
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