2. Neuronal Signaling
  3. Monoamine Oxidase
  4. LOX-IN-3 dihydrochloride monohydrate

LOX-IN-3 dihydrochloride monohydrate 

目录号: HY-138625B
产品使用指南

摩尔计算器

LOX-IN-3 dihydrochloride monohydrate (Compound 33) 是一种具有口服活性的赖氨酰氧化酶 (lysyl oxidase (LOX)) 抑制剂，可用于纤维化，癌症和血管生成研究。

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LOX-IN-3 dihydrochloride monohydrate Chemical Structure

LOX-IN-3 dihydrochloride monohydrate Chemical Structure

CAS No. : 2414974-55-1

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LOX-IN-3 dihydrochloride monohydrate 的其他形式现货产品:

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Other Forms of LOX-IN-3 dihydrochloride monohydrate:

LOX-IN-3 dihydrochloride monohydrate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LOX-IN-3 dihydrochloride monohydrate (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride monohydrate can be used for fibrosis, cancer and angiogenesis research[1].

IC50 & Target

IC50: <1 μM (human LOXL2), <10 μM (bovine LOX)[1]
体外研究
(In Vitro)

LOX-IN-3 dihydrochloride monohydrate (Compound 33) inhibits the bovine LOX and human LOXL2 activities with IC50 values of <10 μM and <1 μM, respectively[1].
LOX-IN-3 dihydrochloride monohydrate exhibits sustained inhibition of LOXL1 and LOXL2[1].
LOX-IN-3 dihydrochloride monohydrate is less active against SSAO/VAP-1 and MAO-B activities[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LOX-IN-3 dihydrochloride monohydrate 相关抗体:
体内研究
(In Vivo)

LOX-IN-3 dihydrochloride monohydrate (Compound 33) (30 mg/kg; orally; once) inhibits lysyl oxidase activity in rats[1].
LOX-IN-3 dihydrochloride monohydrate (10 mg/kg; orally; daily for 14 days) reduces kidney fibrosis in unilateral ureteric obstruction (UUO) mice model[1].
LOX-IN-3 dihydrochloride monohydrate (15 mg/kg; orally; daily for 21 days) reduces lung fibrosis in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 30 mg/kg
Administration: Oral administration, single dose
Result: Completely abolished lysyl oxidase activity. Plasma concentrations of tested compound are far below the IC50 after 8 hours, the half-life of recovery is between 2-3 days (ear) and 24 hours (aorta).
Animal Model: Unilateral ureteric obstruction (UUO) model of acute kidney fibrosis in mice[1]
Dosage: 10 mg/kg
Administration: Oral gavage, daily for 14 days
Result: Increased kidney weight and thickness and reduced the area of fibrosis.
Animal Model: C57Bl/6 mice, Bleomycin-induced lung fibrosis model
Dosage: 15 mg/kg
Administration: Oral gavage, daily for 21 days
Result: Significantly reduced the Ashcroft score and the lung weight.
分子量

371.26

Formula

C13H17Cl2FN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LOX-IN-3 dihydrochloride monohydrate 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LOX-IN-3 dihydrochloride2414974-55-1Monoamine OxidaseMAOfibrosislysyl oxidaseLOXL2Inhibitorinhibitorinhibit

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