2. Neuronal Signaling
  3. Monoamine Oxidase
  4. PXS-5505

PXS-5505  (Synonyms: LOX-IN-3 dihydrochloride monohydrate)

目录号: HY-138625B
产品使用指南 技术支持

PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (Compound 33) 是一种具有口服活性的赖氨酰氧化酶 (lysyl oxidase (LOX)) 抑制剂，可用于纤维化，癌症和血管生成研究。

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PXS-5505

PXS-5505 Chemical Structure

CAS No. : 2414974-55-1

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PXS-5505 的其他形式现货产品:

Customer Review

Other Forms of PXS-5505:

PXS-5505 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

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MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 can be used for fibrosis, cancer and angiogenesis research[1].

IC50 & Target

IC50: <1 μM (human LOXL2), <10 μM (bovine LOX)[1]
体外研究
(In Vitro)

PXS-5505 (Compound 33) 可抑制牛 LOX 和人 LOXL2 的活性，IC50 值分别为 <10 μM 和 <1 μM[1]。
PXS-5505 对 LOXL1 和 LOXL2 具有持续抑制作用[1]。
PXS-5505 对 SSAO/VAP-1 和 MAO-B 的活性较低[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PXS-5505 相关抗体:
体内研究
(In Vivo)

PXS-5505 (Compound 33) (30 mg/kg；口服；一次) 可抑制大鼠赖氨酰氧化酶活性[1]。
PXS-5505 (10 mg/kg；口服；每日一次，共 14 天) 可减轻单侧输尿管梗阻 (UUO) 小鼠模型中的肾脏纤维化[1]。
PXS-5505 (15 mg/kg；口服；每日一次，共 21 天) 可减轻小鼠的肺纤维化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 30 mg/kg
Administration: Oral administration, single dose
Result: Completely abolished lysyl oxidase activity. Plasma concentrations of tested compound are far below the IC50 after 8 hours, the half-life of recovery is between 2-3 days (ear) and 24 hours (aorta).
Animal Model: Unilateral ureteric obstruction (UUO) model of acute kidney fibrosis in mice[1]
Dosage: 10 mg/kg
Administration: Oral gavage, daily for 14 days
Result: Increased kidney weight and thickness and reduced the area of fibrosis.
Animal Model: C57Bl/6 mice, Bleomycin-induced lung fibrosis model
Dosage: 15 mg/kg
Administration: Oral gavage, daily for 21 days
Result: Significantly reduced the Ashcroft score and the lung weight.
分子量

371.26

Formula

C13H17Cl2FN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PXS-5505 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PXS-55052414974-55-1LOX-IN-3 dihydrochloridePXS5505PXS 5505Monoamine OxidaseMAOfibrosislysyl oxidaseLOXL2Inhibitorinhibitorinhibit

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