2. Immunology/Inflammation
  3. COX
  4. Loxoprofen sodium (dihydrate)

Loxoprofen sodium (dihydrate)  (Synonyms: 洛索洛芬钠二水合物)

目录号: HY-B0578B
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Loxoprofen sodium dihydrate 是一种具有口服活性和解热作用的非甾体类抗炎药，可用于缓解疼痛的研究。Loxoprofen sodium dihydrate 是一种非选择性 COX 抑制剂，对 COX-1 和 COX-2 的 IC50 分别为 6.5 和 13.5 μM。Loxoprofen sodium dihydrate 可降低动脉粥样硬化，并具有抗肿瘤活性。

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Loxoprofen sodium (dihydrate) Chemical Structure

Loxoprofen sodium (dihydrate) Chemical Structure

CAS No. : 226721-96-6

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Loxoprofen sodium (dihydrate) 的其他形式现货产品:

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Loxoprofen sodium (dihydrate) 相关抗体

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COX COX-1 COX-2 COX-3

  • 生物活性

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  • 参考文献

生物活性

Loxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity[1][2][3][4].

IC50 & Target

COX-1

6.5 μM (IC50, in human whole blood)

COX-2

13.5 μM (IC50, in human whole blood)

体外研究
(In Vitro)

Loxoprofen sodium dihydrate, an anti-inflammatory prodrug (NSAID), is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2 in human whole blood assays, respectively[1].
Loxoprofen (LOX) sodium dihydrate is a non-selective cyclooxygenase inhibitor that is widely used for the reasearch of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by carbonyl reductase (CR) and they consist of trans-LOX, which is active, and cis-LOX, which is inactive. In addition, LOX sodium dihydrate can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Loxoprofen sodium (dihydrate) 相关抗体:
体内研究
(In Vivo)

Loxoprofen sodium (4 mg/kg/day; p.o.; 1 or 8 weeks) dihydrate reduces atherosclerosis in mice by reducing inflammation[3]. Loxoprofen sodium (60 μg/mL; p.o.; 24 days) dihydrate suppresses mouse tumor growth by inhibiting VEGF[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ApoE-/- mice (C57BL/6J-Apoetm1Unc) with high-fat diet (0.2% cholesterol, 21% saturated fat) from 8 to 16 weeks of age[3]
Dosage: 4 mg/kg/day in drinking water
Administration: Oral dosing from 8 to 16 weeks of age or from 15 to 16 weeks of age
Result: Inhibited platelet thromboxane production and platelet aggregation. Reduced extent of atherosclerosis. Suppressed the production of PGE2, TxB2 and PGI2.
Animal Model: 6-week-old male C57BL/6 and BDF1 mice, 100 μL suspensions (2 × 106 cells/mL) of LLC cells and KLN205 cells were injected subcutaneously into C57BL/6 and BDF1 mice, respectively[4].
Dosage: 60 μg/mL
Administration: Oral dosing in drinking water, every day for 24 days
Result: Suppressed tumor growth and angiogenesis, suppressed expression of VEGF in mice with LLC tumor, inhibited tubular formation of HUVECs.
Clinical Trial
分子量

304.31

Formula

C15H21NaO5
CAS 号
中文名称

洛索洛芬钠二水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Loxoprofen sodium (dihydrate) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Loxoprofen sodium (dihydrate)226721-96-6洛索洛芬钠二水合物COXCyclooxygenasepaininflammationNSAIDanalgesicHUVECsLLCVEGFatherosclerosisInhibitorinhibitorinhibit

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