2. Cell Cycle/DNA Damage
  3. CDK
  4. LQ23

LQ23 是 CDC2 样激酶 2 (CLK2) 的选择性抑制剂，IC50 为 1.4 nM。LQ23 具有抗炎活性。

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LQ23 Chemical Structure

LQ23 Chemical Structure

CAS No. : 2997615-62-8

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LQ23 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LQ23 is a selective inhibitor for CDC2-like kinase 2 (CLK2) with an IC50 of 1.4 nM. LQ23 exhibits anti-inflammatory activity[1].

IC50 & Target

IC50: 1.4 nM (CLK2), 2.1 nM (CLK1), 3.2 nM (CLK4), 21.7 nM (DYRK1A), >100 nM (CLK3)
体外研究
(In Vitro)

LQ23 (10-100 nM) 剂量依赖性地抑制软骨细胞中 SR 蛋白磷酸化，从而调节基因的选择性切割[1]。
LQ23 (10-100 nM) 剂量依赖性地抑制 HEK-293T 细胞中 CHIR99021 刺激的 Wnt 信号传导，IC50 为 2.9 μM[1]。
LQ23 (30 nM) 通过促进骨间充质干细胞 (BMSC) 分化为软骨细胞并抑制软骨退化来改善骨关节炎[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LQ23 相关抗体:

Western Blot Analysis[1]

Cell Line: Chondrocytes
Concentration: 10-100 nM
Incubation Time: 1 h
Result: Reduced phosphorylated SRSF4, SRSF5 and SRSF6.
Reduced levels of β-catenin and c myc.
体内研究
(In Vivo)

LQ23 (1.5 μg/ kg，单次关节内注射) 在 Sprague-Dawley 大鼠 monosodium iodoacetate (MIA) 或 ACLT-pMMx 诱导的骨关节炎中表现出抑制炎症，保护软骨并改善关节功能的作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MIA-/ACLT-pMMx-induced osteoarthritis in Sprague-Dawley rats model[1]
Dosage: 1.5 μg/ kg
Administration: Single IA injection
Result: Ameliorated the surface of the articular cartilage and the cell arrangement, reduced the thickness of the synovium, increased the gap between the femur and the tibia.
Reduced the levels of inflammatory cytokines and catabolic enzymes.
分子量

416.54

Formula

C24H24N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LQ23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQ232997615-62-8LQ 23LQ-23CDKCyclin dependent kinaseosteoarthritisSprague Dawley ratsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162398
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