2. Apoptosis
  3. TNF Receptor
  4. Lucatumumab

Lucatumumab  (Synonyms: HCD122)

目录号: HY-P99167 纯度: 95.00%
COA

摩尔计算器

Lucatumumab (HCD122) 是一种全人抗 CD40 拮抗剂单克隆抗体，可阻断 CD40/ CD40L 介导的信号通路。Lucatumumab 可有效介导抗体依赖性细胞介导的细胞毒性 (ADCC) 和肿瘤细胞清除，可用于顽固性淋巴瘤、慢性淋巴细胞白血病 (CLL) 和多发性骨髓瘤研究。

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Lucatumumab Chemical Structure

Lucatumumab Chemical Structure

CAS No. : 903512-50-5

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规格 价格 是否有货 数量
1 mg ￥2200
In-stock
5 mg ￥5500
In-stock
10 mg ￥8800
In-stock
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Lucatumumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research[1][2].

IC50 & Target

CD40

 

体外研究
(In Vitro)

Lucatumumab (0.001-10 μg/mL; 4 h; 37 ℃) inhibit B-cell chronic lymphocytic leukemia (B-CLL) growth by ADCC-mediated cell lysis, with the average maximal lysis of B-CLL cells of 49%[1].
Lucatumumab (0.1-10 μg/mL; 3 d) inhibits CD40L-induced signaling and viability of B-CLL cells[1].
Lucatumumab (10 μg/mL; 24 h) inhibits cytokine secretion by B-CLL cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lucatumumab 相关抗体:

Cell Viability Assay[1]

Cell Line: B-cell chronic lymphocytic leukemia (B-CLL)
Concentration: 0.001 to 10 μg/mL
Incubation Time: 72 hours; 37 ℃
Result: Inhibited B-CLL growth with an ED50 of 14 pM and a average maximal lysis of B-CLL cells of 49%.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lucatumumab 相关分类

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lucatumumab903512-50-5HCD122HCD 122HCD-122TNF ReceptorTumor Necrosis Factor ReceptorTNFRPeripheral blood mononuclear cellsPBMCsantibody-dependent cell-mediated cytotoxicityADCCnatural killer cellsNK cellInhibitorinhibitorinhibit

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