2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. Endogenous Metabolite Apoptosis Reactive Oxygen Species
  4. Lutein

Lutein (Xanthophyll) 是一种类胡萝卜素，具有抗炎作用。Lutein 具有多种有益作用，尤其是对眼睛健康。Lutein 通过影响活性氧 (ROS) 发挥抗炎、抗氧化酶、抗凋亡 (apoptosis) 等生物活性。Lutein 能够到达大脑，显示出抗抑郁类和神经保护作用。Lutein 具有口服活性。

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Lutein Chemical Structure

Lutein Chemical Structure

CAS No. : 127-40-2

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规格 价格 是否有货
10 mM * 1 mL in DMSO ￥626
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5 mg ￥500
询问价格 & 货期
10 mg ￥800
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20 mg ￥1400
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Customer Review

Lutein 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health[1]. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS)[2][3]. Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active[4].

体外研究
(In Vitro)

Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lutein 相关抗体:
体内研究
(In Vivo)

Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats[3].
Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats, severe traumatic brain injury (STBI) model[3]
Dosage: 40, 80 and 160 mg/kg
Administration: In diet for 5 weeks
Result: Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.
Animal Model: Male Swiss mice, chronic Corticosterone (HY-B1618) model of depression[4]
Dosage: 0.1, 1 and 10 mg/kg
Administration: Oral administration, once or daily for 7 and 21 days
Result: Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed by Corticosterone (HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.
Clinical Trial
分子量

568.87

Formula

C40H56O2
CAS 号
性状

固体

颜色

Orange to red

中文名称

叶黄素
结构分类
初始来源

egg's yolk
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (87.89 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7579 mL 8.7894 mL 17.5787 mL
5 mM 0.3516 mL 1.7579 mL 3.5157 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 89.49%

COA (184 KB) HNMR (127 KB) LCMS (102 KB)

产品使用指南 (1538 KB)
参考文献

Lutein 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7579 mL 8.7894 mL 17.5787 mL 43.9468 mL
5 mM 0.3516 mL 1.7579 mL 3.5157 mL 8.7894 mL
10 mM 0.1758 mL 0.8789 mL 1.7579 mL 4.3947 mL
15 mM 0.1172 mL 0.5860 mL 1.1719 mL 2.9298 mL
20 mM 0.0879 mL 0.4395 mL 0.8789 mL 2.1973 mL
25 mM 0.0703 mL 0.3516 mL 0.7031 mL 1.7579 mL
30 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4649 mL
40 mM 0.0439 mL 0.2197 mL 0.4395 mL 1.0987 mL
50 mM 0.0352 mL 0.1758 mL 0.3516 mL 0.8789 mL
60 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7324 mL
80 mM 0.0220 mL 0.1099 mL 0.2197 mL 0.5493 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lutein127-40-2Xanthophyll叶黄素Endogenous MetaboliteApoptosisReactive Oxygen SpeciesA2-PEA2Emacular degenerationICAM-1Nrf-2CorticosteroneInhibitorinhibitorinhibit

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