1. GPCR/G Protein
    Neuronal Signaling
  2. Neurotensin Receptor
  3. [Lys8, Lys9]-Neurotensin (8-13)

[Lys8, Lys9]-Neurotensin (8-13) (Synonyms: JMV438)

目录号: HY-P2544
产品使用指南

[Lys8, Lys9]-Neurotensin (8-13) (JMV438) 是神经降压素的类似物,通过激活 G 蛋白偶联受体 NTS1NTS2 来发挥镇痛作用,其对 hNTS1 和 hNTS2 受体的 Ki 值分别为 0.33 nM 和 0.95 nM。

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Custom Peptide Synthesis

[Lys8, Lys9]-Neurotensin (8-13) Chemical Structure

[Lys8, Lys9]-Neurotensin (8-13) Chemical Structure

CAS No. : 139026-64-5

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Description

[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].

Molecular Weight

761.00

Formula

C₃₈H₆₄N₈O₈

CAS No.

139026-64-5

Sequence Shortening

KKPYIL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

[Lys8, Lys9]-Neurotensin (8-13)JMV438JMV 438JMV-438Neurotensin ReceptorInhibitorinhibitorinhibit

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产品名称:
[Lys8, Lys9]-Neurotensin (8-13)
目录号:
HY-P2544
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