2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. MAGL Calcium Channel
  4. MAGL-IN-13

MAGL-IN-13（compound(3R,4S)-5v）是一种有选择性的，不可逆的 MAGL 抑制剂，mMAGL，hMAGL 和 rMAGL 的IC50 值分别是 0.026，0.021 和 0.24 nM。MAGL-IN-13 具有血脑屏障穿透性。

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MAGL-IN-13 Chemical Structure

MAGL-IN-13 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

MAGL-IN-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAGL-IN-13 (compound (3R, 4S) - 5v) is a selective, irreversible inhibitor for MAGL,with IC50 values of 0.026, 0.021 and 0.24 nM for mMAGL, hMAGL and rMAGL, respectively. MAGL-IN-13 can penetrant blood brain barrier. [1].

IC50 & Target

rats Ca2+ channel (10 μM)[1]
体外研究
(In Vitro)

MAGL-IN-13 （37 ℃预孵育 10 分钟）可以抑制mMAGL，hMACL 和 rMACL，IC50 值分别是0.026，0.021 和0.24 nM[1]。
MAGL-IN-13 不可逆的抑制 MAGL 活性[1]。
MAGL-IN-13（0.1 和 1 μM）对 MAGL 具有选择性[1]。
MAGL-IN-13 在小鼠成纤维细胞 NIH3T3 中显示低细胞毒性，细胞活力的IC50值是 0.47 μM[1]。
MAGL-IN-13 在10 μM 浓度下可以抑制大鼠的 Ca2+ 通道[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAGL-IN-13 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: NIH 3T3
Concentration: 4, 13, 22, 34, 47, 60 μM
Incubation Time: 24 h
Result: Exhibited low cytotoxic potential.

Cell Viability Assay[1]

Cell Line: NIH 3T3
Concentration: 4, 13, 22, 34, 47, 60 μM
Incubation Time: 24 h
Result: Revealed an IC50 of 47 μM.
体内研究
(In Vivo)

MAGL-IN-13（腹腔注射，5 mg/kg）抑制大脑 MAGL 的活性，具有剂量依赖性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MAGL inhibition/adult male mice [1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited brain MAGL activity.
分子量

513.52

Formula

C28H24FN5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAGL-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAGL-IN-13MAGLCalcium ChannelMonoacylglycerol lipaseCa2+ channelsCa channelsInhibitorinhibitorinhibit

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产品名称：
MAGL-IN-13
目录号：
HY-163202
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