2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-22

MAO-B-IN-22 (compound 6h) 是一种有效的MAO-B抑制剂，其 IC50 值为 0.014 μM。MAO-B-IN-22 具有高抗氧化活性、良好的金属螯合能力、适当的 BBB 通透性和显着的神经保护作用。

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MAO-B-IN-22 Chemical Structure

MAO-B-IN-22 Chemical Structure

CAS No. : 2902600-76-2

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MAO-B-IN-22 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect[1].

体外研究
(In Vitro)

MAO-B-IN-22 (compound 6h) (2.5-50 μM, 24 h) 可以剂量依赖性的保护过氧化氢诱导的氧化损伤，提高细胞活力[1]。
MAO-B-IN-22 (compound 6h) (0.5-10 μM, 24 h) 可以剂量依赖性的降低 LPS 诱导的 NO 产生，具有抗神经炎症活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-22 相关抗体:

Cell Viability Assay[1]

Cell Line: PC-12 cells
Concentration: 2.5 μM, 10.0 μM, 50.0 μM
Incubation Time: 24 h
Result: Increased cell viability to 59.8%, 69.6% and 77.2% of the control value at doses of 2.5 μM, 10.0 μM and 50.0 μM, respectively.

Western Blot Analysis[1]

Cell Line: BV-2 cells
Concentration: 0.5 μM, 2.5 μM, 10.0 μM
Incubation Time: 24 h
Result: Significantly reduced LPS-induced NO production by 13.5%, 28.0% and 76.1% at concentrations of 0.5 μM, 2.5 μM and 10.0 μM, respectively.
Inhibited the release of ROS induced by lipopolysaccharide, and the inhibitory rates were 21.2% and 99.0% at the concentration of 2.5 μM and 10.0 μM , respectively.
Significantly inhibited the phosphorylation of IκBα to p-IκBα, and inhibited the translocation of p65 from the cytoplasm to the nucleus.
体内研究
(In Vivo)

MAO-B-IN-22 (compound 6h)(53.5 mg/kg, oral gavage, once a day for 3 weeks) 可以通过抑制 MAO-B 增加多巴胺能神经递质水平和减少 ROS 引起的氧化损伤水平来减轻小鼠的运动损伤，可以减轻 MPTP 治疗小鼠的运动障碍，并可能改善体内 PD 的症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6C mice[1]
Dosage: 53.5 mg/kg
Administration: oral gavage, once a day for 3 weeks
Result: Significantly improved traction test scores and reduced BWT times, T-turns and T-totals.
Restored DA levels and reduce MDA levels.
分子量

323.36

Formula

C20H18FNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-22 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-222902600-76-2Monoamine OxidaseMAOantioxidantmetal chelating abilityBBBneuroprotectiveInhibitorinhibitorinhibit

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