2. Neuronal Signaling
  3. Monoamine Oxidase Cholinesterase (ChE) Amyloid-β
  4. MAO-B-IN-48

MAO-B-IN-48 是一种选择性 MAO-B 抑制剂 (IC50 = 0.09 μM，Ki = 0.02 μM)。MAO-B-IN-48 对 hBChE (IC50 = 1.10 μM，Ki = 0.43 μM) 和 AChE (IC50 = 0.56 μM，Ki = 0.14 μM) 表现出抑制活性。MAO-B-IN-48 抑制毒性β-淀粉样肽的自诱导聚集，并具有抗氧化活性，包括 DPPH 自由基清除、CUPRAC 铜离子还原和超氧阴离子清除。MAO-B-IN-48 可用于阿尔茨海默病 (AD) 研究。

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MAO-B-IN-48

MAO-B-IN-48 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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Customer Review

MAO-B-IN-48 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-48 is a selective MAO-B inhibitor (IC50 = 0.09 μM, Ki = 0.02 μM). MAO-B-IN-48 exhibits inhibitory activity against hBChE (IC50 = 1.10 μM, Ki = 0.43 μM) and AChE (IC50 = 0.56 μM, Ki = 0.14 μM). MAO-B-IN-48 suppresses self-induced aggregation of toxic β-amyloid peptides and exerts antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. MAO-B-IN-48 can be used for the study of Alzheimer's disease (AD)[1].

IC50 & Target[1]

MAO-B

0.09 μM (IC50)

MAO-B

0.02 μM (Ki)

MAO-A

30.55 μM (IC50)

MAO-A

8.33 μM (Ki)

AChE

0.56 μM (IC50)

AChE

0.14 μM (Ki)

hBCHE

1.10 μM (IC50)

hBCHE

0.43 μM (Ki)

体外研究
(In Vitro)

MAO-B-IN-48 (Compound 1d-R) 在体外抑制 Aβ1-40 (IC50 = 31.42 μM) 和 Aβ1-42 (IC50 = 21.32 μM) 的自诱导聚集[1]。
MAO-B-IN-48 显示出 DPPH 自由基清除活性 (IC50 = 3.40 mM)，在 CUPRAC 实验中具有抗氧化活性 (IC50 = 33.40 μM) 以及超氧阴离子清除能力 (IC50 = 28.21 μM)[1]。
MAO-B-IN-48 (1-25 μM) 对 HepG2 细胞无细胞毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-48 相关抗体:
体内研究
(In Vivo)

MAO-B-IN-48 (20 mg/kg，灌胃给药，一周) 可改善由 AlCl3 引起的小鼠认知障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 40mg/kg of AlCl3 was administered intraperitoneally to male Balb/c mice for 30 days[1]
Dosage: 20 mg/kg
Administration: i.g. for 1 week
Result: Ameliorated the cognitive impairment induced by AlCl3 in mice.
分子量

350.48

Formula

C21H22N2OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-48 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-48Monoamine OxidaseCholinesterase (ChE)Amyloid-βMAOβ-amyloid peptideAβAbetaAlzheimer's diseaseMAO-BAChEBChEβ-amyloid peptidesInhibitorinhibitorinhibit

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