2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Margatoxin

Margatoxin  (Synonyms: 玛格斑蝎毒素)

目录号: HY-P1280 纯度: 98.67%
COA 产品使用指南

摩尔计算器

Margatoxin 是一种 α-KTx 蝎毒素，一种高亲和力的 Kv1.3 抑制剂，Kd 为 11.7 pM。Margatoxin 抑制 Kv1.2 和 Kv1.1 通道，Kd 值分别为 6.4 pM，4.2 nM。Margatoxin 是一种 39 个氨基酸的肽，是从玛格丽特蝎 (Centruroides margaritatus) 蝎毒中分离得到的，广泛用于离子通道研究。

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Custom Peptide Synthesis

Margatoxin Chemical Structure

Margatoxin Chemical Structure

CAS No. : 145808-47-5

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规格 价格 是否有货 数量
100 μg ￥1500
In-stock
500 μg ￥4600
In-stock
1 mg ￥6800
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of Margatoxin:

Margatoxin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2].

IC50 & Target

Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1]
体内研究
(In Vivo)

在 12 周龄的 C57BL6/J 小鼠中，Margatoxin (ip；1 pmol/g) 显著降低硫代乙醇酸盐诱导的腹腔白细胞迁移[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4178.95

Formula

C178H286N52O50S7
CAS 号
性状

固体

颜色

White to off-white

Sequence

Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)
Sequence Shortening

TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH(Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)
中文名称

玛格斑蝎毒素
结构分类
初始来源

Centruroides margaritatus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

纯度 & 产品资料
参考文献

Margatoxin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Margatoxin145808-47-5玛格斑蝎毒素Potassium ChannelKcsAalpha-KTxscorpiontoxinKv1.3Kv1.2Kv1.139amino-acid-longpeptideCentruroidesmargaritatuschannelInhibitorinhibitorinhibit

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