2. Anti-infection
  3. SARS-CoV
  4. Masavibart

Masavibart  (Synonyms: ZRC3308-A7)

目录号: HY-145642

摩尔计算器

Masavibart (ZRC3308-A7) 是一种靶向 SARS-CoV-2 的单克隆抗体 (IgG1 型)。Masavibart 对 SARS-CoV-2 穗状蛋白的 RBD 上的非竞争性表位显示出良好的结合亲和力。Masavibart 可按 1:1 与 ZRC3308-B10 (HY-145643) 联合使用，对 COVID-19 的预防以及尚未发展为严重疾病的早期 COVID-19 有效。

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Masavibart Chemical Structure

Masavibart Chemical Structure

CAS No. : 2640223-84-1

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Masavibart 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Masavibart (ZRC3308-A7) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Masavibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Masavibart can be used in combination with ZRC3308-B10 (HY-145643) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease[1].

IC50 & Target

SARS-CoV-2[1].
体外研究
(In Vitro)

Masavibart (ZRC3308-A7; 0-56 ng/mL) 与 ZRC3308-B10 按 1:1 联合时，在 VeroE6/Vero CCL81 (SARS-CoV-2 感染模型) 中显示出病毒中和活性[1]。 Masavibart 与 ZRC3308-B10 按 1:1 联合时，在体外中和 SARS-CoV-2 变体 B.1B.1.7、B.1.351、B.1.617.2 和 B.1.617.2 A Y .1[1]。
Masavibart 与 SARS-CoV-2 S1 蛋白的 RBD 结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Masavibart 相关抗体:

Cell Viability Assay[1]

Cell Line: VeroE6/Vero CCL81 cells (SARS-CoV-2 infection model)
Concentration: 0-5×105 ng/mL (in combination with ZRC3308-B10)
Incubation Time: 72 h
Result: Showed potent neutralization activity with an IC50 of 0.1527 ng/mL.
体内研究
(In Vivo)

Masavibart (ZRC3308-A7; 0.5, 2.5, 25 mg/kg; SARS-CoV-2 感染前 48 小时给药) 当与 ZRC3308-B10 联合 （1:1 联合）时，能有效预防叙利亚仓鼠的 SARS-CoV-2 感染[1]。
Masavibart (0.5, 2.5, 25 mg/kg; i.p.; single) 在长达七天的时间里，血清浓度保持不变，没有太多减少（在叙利亚仓鼠体内）[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female syrian hamster (7 to 10-week-old; SARS-CoV-2 infection model)[1].
Dosage: 0.5, 2.5, 25 mg/kg
Administration: Intraperitoneal injection; 48 h prior to the SARS-CoV-2 infection
Result: Prevented SARS-CoV-2 infection when in combination with ZRC3308-B10.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Masavibart 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Masavibart2640223-84-1ZRC3308-A7SARS-CoVSARS coronavirusCOVID-19RBDVeroE6/Vero CCL81 cellInhibitorinhibitorinhibit

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