2. Academic Validation
  3. Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus

Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus

  • J Nat Prod. 1999 Jun;62(6):895-7. doi: 10.1021/np980462e.
X Shen 1,  S B Krasnoff,  S W Lu,  C D Dunbar,  J O'Neal,  B G Turgeon,  O C Yoder,  D M Gibson,  M T Hamann
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, National Center for the Development of Natural Products, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
PMID: 10395513 DOI: 10.1021/np980462e
Abstract

The new sesterterpenoid 6-epi-3-anhydroophiobolin B (1) and six known ophiobolins were isolated from the extracts of the fungus Cochliobolus heterostrophus race O. The structure of 6-epi-3-anhydroophiobolin B was deduced from analysis of spectral data and the structural characterization of dehydration and dimerization products. Ophiobolin A (2) showed potent activity in cytotoxicity assays and marginal activity in antimalarial assays.

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