2. Academic Validation
  3. C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study

C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study

  • Bioorg Med Chem Lett. 1999 Jul 19;9(14):2085-8. doi: 10.1016/s0960-894x(99)00335-2.
M T Goulet 1,  P J Sinclair,  F Wong,  M J Staruch,  F J Dumont,  J G Cryan,  G J Wiederrecht,  M J Wyvratt,  W H Parsons
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
PMID: 10450986 DOI: 10.1016/s0960-894x(99)00335-2
Abstract

A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.

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