2. Academic Validation
  3. 8-aminoquinolines as anticoccidials - Part III

8-aminoquinolines as anticoccidials - Part III

  • Bioorg Med Chem Lett. 1999 Aug 16;9(16):2425-30. doi: 10.1016/s0960-894x(99)00393-5.
R E Armer 1,  J S Barlow,  N Chopra,  C J Dutton,  D H Greenway,  S D Greenwood,  N Lad,  J Shaw,  A P Thompson,  K W Thong,  I Tommasini
Affiliations

Affiliation

  • 1 Animal Health Discovery, Pfizer Central Research, Kent.
PMID: 10476881 DOI: 10.1016/s0960-894x(99)00393-5
Abstract

Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated. Novel analogues of equal or improved efficacy in vitro and in vivo to pentaquine were discovered.

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