2. Academic Validation
  3. (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist

(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist

  • Bioorg Med Chem Lett. 2000 Jun 5;10(11):1241-4. doi: 10.1016/s0960-894x(00)00197-9.
F Gasparini 1,  W Inderbitzin,  E Francotte,  G Lecis,  P Richert,  Z Dragic,  R Kuhn,  P J Flor
Affiliations

Affiliation

  • 1 Nervous System Research, Novartis Pharma AG, Basel, Switzerland. fabrizio.gasparini@pharma.novartis.com
PMID: 10866390 DOI: 10.1016/s0960-894x(00)00197-9
Abstract

A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III Metabotropic Glutamate Receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.

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