2. Academic Validation
  3. Flavonoids: structural requirements for antiproliferative activity on breast cancer cells

Flavonoids: structural requirements for antiproliferative activity on breast cancer cells

  • Bioorg Med Chem Lett. 2001 Dec 17;11(24):3095-7. doi: 10.1016/s0960-894x(01)00617-5.
C Pouget 1,  F Lauthier,  A Simon,  C Fagnere,  J P Basly,  C Delage,  A J Chulia
Affiliations

Affiliation

  • 1 UPRES EA 1085, 'Biomolécules et cibles cellulaires tumorales', Faculté de Pharmacie, 2 rue du Docteur Marcland, 87025 Cedex, Limoges, France.
PMID: 11720850 DOI: 10.1016/s0960-894x(01)00617-5
Abstract

Several classes of Flavonoids (Flavones, flavanones, 2'-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast Cancer cells. Structure-activity relationships of these compounds were discussed. 2'-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas Flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone.

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