2. Academic Validation
  3. Novel bicyclic oxazolone derivatives as anti-angiogenic agents

Novel bicyclic oxazolone derivatives as anti-angiogenic agents

  • Bioorg Med Chem Lett. 2002 Jun 3;12(11):1463-6. doi: 10.1016/s0960-894x(02)00197-x.
Françoise M Perron-Sierra 1,  Alain Pierré,  Mike Burbridge,  Nicolas Guilbaud
Affiliations

Affiliation

  • 1 Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France. francoise.perron@fr.netgrs.com
PMID: 12031320 DOI: 10.1016/s0960-894x(02)00197-x
Abstract

Novel bicyclic tetrahydropyrano[3,2-d]oxazolones derivatives, analogues of Fumagillin, were synthesised via a stereocontrolled oxidative-rearrangement of furylcarbinols and subsequent treatment with the appropriate isocyanate. These compounds demonstrated potent antiangiogenic activity.

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