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  3. Structure-activity relationships studies of the anti-angiogenic activities of linomide

Structure-activity relationships studies of the anti-angiogenic activities of linomide

  • Bioorg Med Chem Lett. 2003 Mar 24;13(6):1187-9. doi: 10.1016/s0960-894x(03)00047-7.
Jiandong Shi 1,  Zili Xiao,  Michael A Ihnat,  Chandrashekhar Kamat,  Bulbul Pandit,  Zhigen Hu,  Pui-Kai Li
Affiliations

Affiliation

  • 1 Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
PMID: 12643940 DOI: 10.1016/s0960-894x(03)00047-7
Abstract

The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.

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